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A randomised placebo-controlled study of the effects of lysergic acid diethylamide microdosing (15 μg) on pain perception in healthy volunteers.

Mauro Cavarra, Nadia R. P. W. Hutten, Jan Schepers, Natasha L. Mason, Eef L. Theunissen, Matthias E. Liechti, Kim P. C. Kuypers, Valerie Bonnelle, Amanda Feilding, Johannes G. Ramaekers

Br J Pain September 4, 2025 DOI: 10.1177/20494637251371626 (opens in new tab)

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Study at a glance

AI-extracted from the abstract

Characteristics	Randomized controlled trial Placebo-controlled Peer reviewed
Population	Healthy volunteers
Dose	15 μg
Topics	LSD Microdosing
Key findings	A 15 μg microdose of LSD did not significantly affect pain perception in healthy volunteers compared to placebo.

Abstract

A randomised placebo-controlled study of the effects of lysergic acid diethylamide microdosing (15 μg) on pain perception in healthy volunteers.