Fitoterapia
September 1, 2023
M E González-trujano, N Páez-martínez, Felix Krengel et al.
4 citations
Tabernaemontana arborea (Apocynaceae) is a Mexican tree species known to contain ibogan type alkaloids. This study aimed at determining central nervous system-related activities of an alkaloid extract obtained from the root bark of T. arborea. A gas chromatography-mass spectrometry (GC-MS) analysis was performed to describe the alkaloid profile of the extract. A wide dosing range (0.1 to 56.2...
Planta Medica
February 1, 2023
Julio César Carrero, Violeta Curay-Herrera, Lysette Chacón-niño et al.
6 citations
Plants of Tabernaemontana species have several pharmacological activities including antimicrobial effects. Amoebiasis continues to be a public health problem, with increasing evidence of resistance to metronidazole. In this study, we assessed the effect of the alkaloid fraction of T. arborea root bark and the alkaloids ibogaine and voacangine on the viability and infectivity of Entamoeba...
Neurotoxicology
March 1, 2022
María Eva González-Trujano, Felix Krengel, Ricardo Reyes-Chilpa et al.
14 citations
Several Apocynaceae species, most notably Tabernanthe iboga, Voacanga africana and many Tabernaemontana species, produce ibogan-type alkaloids. Although a large amount of information exists about the Tabernaemontana genus, knowledge concerning chemistry and biological activity remains lacking for several species, especially related to their effects on the central nervous system (CNS). The aim...
Chemistry & Biodiversity
May 1, 2020
Felix Krengel, Jonathan Dickinson, Christopher Jenks et al.
7 citations
In continuation of our efforts to provide quantitative information on antiaddictive ibogan type alkaloid-producing Tabernaemontana species, we used gas chromatography-mass spectrometry (GC/MS) to compare the alkaloid profiles of the barks and/or leaves of one Mexican and one African species - T. arborea and T. crassa, respectively, with the primary sources of commercially available...
Chemistry & Biodiversity
July 1, 2019
Felix Krengel, Marco V Mijangos, Marisol Reyes-Lezama et al.
17 citations
Several species from the Apocynaceae family, such as Tabernanthe iboga, Voacanga africana, and many Tabernaemontana species, produce ibogan type alkaloids, some of which present antiaddictive properties. In this study, we used gas chromatography/mass spectrometry (GC/MS) to examine the efficiency of methanol, acetone, ethyl acetate, dichloromethane, chloroform, and hydrochloric acid in...
Chemistry & Biodiversity
April 1, 2019
Felix Krengel, Quentin Chevalier, Jonathan Dickinson et al.
10 citations
Ibogaine and other ibogan type alkaloids present anti-addictive effects against several drugs of abuse and occur in different species of the Apocynaceae family. In this work, we used gas chromatography-mass spectrometry (GC/MS) and principal component analysis (PCA) in order to compare the alkaloid profiles of the root and stem barks of four Mexican Tabernaemontana species with the root bark of...
Chemistry & Biodiversity
December 1, 2016
Felix Krengel, Josefina Herrera Santoyo, Teresa de Jesús Olivera Flores et al.
19 citations
Tabernaemontana alba and Tabernaemontana arborea are Apocynaceae species used in Mexican traditional medicine for which little phytochemical information exists. In this study, preliminary gas chromatography/mass spectrometry analyses of different organs obtained from wild plants of both species identified a total of 10 monoterpenoid indole alkaloids (MIAs) and one simple indole alkaloid, nine...