PLoS One
October 13, 2025
Francisco González-espejito, Laura Esteban Rodríguez, Eduardo J. Pedrero Pérez et al.
Ibogaine, an indole alkaloid derived from the root bark of Tabernanthe iboga, has long been used in traditional Bwiti healing rituals and shows promise for treating opioid dependence and neurological conditions, but existing psychometric tools fail to capture its distinctive subjective/oneiric (dream-like) effects. To address this gap, we developed the 70-item Ibogaine Experience Scale (IES)...
Frontiers in Immunology
2025
David Qixiang Chen, José Adalberto Inzunza Domínguez, Juan Manuel Valle Uzeta et al.
3 citations
Multiple sclerosis (MS) is a debilitating neurodegenerative disease characterized by demyelination and neuronal loss. Traditional therapies often fail to halt disease progression or reverse neurological deficits. Ibogaine, a psychoactive alkaloid, has been proposed as a potential neuroregenerative agent due to its multifaceted pharmacological profile. We present two case studies of MS patients...
Nature Medicine
February 1, 2024
Kirsten Cherian, Jackob N. Keynan, Lauren Anker et al.
66 citations
Traumatic brain injury (TBI) is a leading cause of disability. Sequelae can include functional impairments and psychiatric syndromes such as post-traumatic stress disorder (PTSD), depression and anxiety. Special Operations Forces (SOF) veterans (SOVs) may be at an elevated risk for these complications, leading some to seek underexplored treatment alternatives such as the oneirogen ibogaine, a...
Anthropology of Consciousness
February 6, 2023
Jonathan Dickinson
1 citation
ABSTRACT This report presents the personal experiences of three individuals who ingested iboga or ibogaine in different contexts and for different reasons. Narrative analysis reveals a connection with previously identified phenomenological categories of experience, however demonstrating a wide variability. Most notably, each of these interviewees reported a distinct impression of transpersonal...
Frontiers in pain research (Lausanne, Switzerland)
2023
Jonathan Dickinson, Jose Adalberto Dominguez Inzunza, Liliana Perez-Villa et al.
3 citations
Brachial plexus nerve root avulsion results from complete separation of the nerve root from the spinal cord and is one of the most challenging types of neuropathic pain, coinciding with motor, sensory and autonomic deficits. The severe pain and typical impossibility of root reattachment often leads to requests for amputation. Ibogaine is an indole alkaloid producing psychoactive effects through...
Chemistry & Biodiversity
May 1, 2020
Felix Krengel, Jonathan Dickinson, Christopher Jenks et al.
7 citations
In continuation of our efforts to provide quantitative information on antiaddictive ibogan type alkaloid-producing Tabernaemontana species, we used gas chromatography-mass spectrometry (GC/MS) to compare the alkaloid profiles of the barks and/or leaves of one Mexican and one African species - T. arborea and T. crassa, respectively, with the primary sources of commercially available...
Chemistry & Biodiversity
April 1, 2019
Felix Krengel, Quentin Chevalier, Jonathan Dickinson et al.
10 citations
Ibogaine and other ibogan type alkaloids present anti-addictive effects against several drugs of abuse and occur in different species of the Apocynaceae family. In this work, we used gas chromatography-mass spectrometry (GC/MS) and principal component analysis (PCA) in order to compare the alkaloid profiles of the root and stem barks of four Mexican Tabernaemontana species with the root bark of...