Journal of the Mexican Chemical Society
July 7, 2026
Aylín R. Tabal-Robles, Jesús Martín Torres-Valencia, Leticia Romero-Bautista et al.
The genus Psilocybe currently comprises approximately 165 species that are hallucinogenic. Chemical studies on them have revealed the presence of alkaloids with indole and β-carboline structures, which are responsible for their psychotropic properties. However, scarce information has been reported on other classes of metabolites present in Psilocybe mushrooms. The objective of this review was...
Molecules
April 18, 2026
Flor Eréndira Sánchez-cortés, Nelly Maritza Vega-Rivera, Raúl Iván Escamilla-Orozco et al.
Mushroom use dates back to ancient times, and it currently remains significant among indigenous and urban populations as a medicinal option. Psilocybe species are suggested to modify emotions when administered in macro- or microdose form for the treatment of anxiety and depression, both often affected by a delayed onset and adverse effects of current pharmacological therapy. The objective of...
Journal of Ethnopharmacology
February 10, 2024
Alberto Hernández-león, Raúl Iván Escamilla-Orozco, Aylín R. Tabal-Robles et al.
29 citations
Central nervous system (CNS) diseases can be diverse and usually present with comorbidity, as in the case of depression and anxiety. Despite alternatives like Psilocybe mushrooms for mental health there is no basic research to evidence their CNS benefits. To evaluate the anxiolytic- and antidepressant-like effects, as well as the acute toxicity of P. cubensis mushroom. First, the acute toxicity...
Journal of Psychoactive Drugs
August 18, 2023
Raul Escamilla, María Eva González-Trujano, Jesús M. González Mariscal et al.
7 citations
The pharmacological treatment of depression consists of taking antidepressant drugs for prolonged periods; its modest therapeutic effect can often be associated with significant adverse effects, while its discontinuation can lead to relapses. Psilocybin is today a novel and breakthrough therapy for major depression. It is a natural alkaloid in Psilocybe mushrooms, which are endemic to Mexico....
Neurotoxicology
March 1, 2022
María Eva González-Trujano, Felix Krengel, Ricardo Reyes-Chilpa et al.
14 citations
Several Apocynaceae species, most notably Tabernanthe iboga, Voacanga africana and many Tabernaemontana species, produce ibogan-type alkaloids. Although a large amount of information exists about the Tabernaemontana genus, knowledge concerning chemistry and biological activity remains lacking for several species, especially related to their effects on the central nervous system (CNS). The aim...
Phytotherapy research : PTR
July 1, 2016
María Eva González-Trujano, Fernando Brindis, Edith López-ruiz et al.
10 citations
Although Salvia divinorum is traditionally known as a 'mind-altering' or psychoactive herb used, among others things, as a tranquilizer, this property has not been validated with regard to its efficacy and safety. The objective of this study is to provide evidence for the sedative effects of S. divinorum and discriminate the nature of the responsible constituents by examining different...