Quantitative Evaluation of a Mexican and a Ghanaian Tabernaemontana Species as Alternatives to Voacanga africana for the Production of Antiaddictive Ibogan Type Alkaloids.
Felix Krengel, Jonathan Dickinson, Christopher Jenks, Ricardo Reyes-Chilpa
Chemistry & Biodiversity May 1, 2020 DOI: 10.1002/cbdv.202000002 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Comparative study Qualitative Peer reviewed |
|---|---|
| Population | Tabernaemontana arborea (Mexican species) and Tabernaemontana crassa (African species) barks and leaves; Voacanga africana root and stem bark |
| Topics | Ibogaine |
| Keywords | Tabernaemontana apocynaceae Voacanga apocynaceae Ibogan type alkaloids Valuable alternative Beneficial alkaloids Voacangine Phytochemical analysis: phytochemistry Alkaloid profiles Compare Findings show Promising new source Primary source T. arborea bark T. crassa V. africana Compounds |
| Citations | 7 |
| Key points | Tabernaemontana arborea bark shows qualitative and quantitative alkaloid similarity to Voacanga africana bark, supporting its potential as an alternative source of voacangine and ibogaine. |
Abstract
In continuation of our efforts to provide quantitative information on antiaddictive ibogan type alkaloid-producing Tabernaemontana species, we used gas chromatography-mass spectrometry (GC/MS) to compare the alkaloid profiles of the barks and/or leaves of one Mexican and one African species - T. arborea and T. crassa, respectively, with the primary sources of commercially available semisynthetic ibogaine, Voacanga africana root and stem bark. The qualitative and quantitative similarities between T. arborea and V. africana barks consolidate previous reports regarding the potential of the former as a promising alternative source of voacangine and ibogaine. The results also suggest that T. crassa could be used to produce conopharyngine and ibogaline, two compounds with the same basic skeletal structure and possibly similar antiaddictive properties as ibogaine.