Burst firing in the lateral habenula (LHb) is enhanced under stress and depression, and ketamine blocks burst firing in LHb to exert a rapid antidepressant effect. Thus, burst firing in LHb may serve as a cellular mechanism of depression and a promising therapeutic target for developing novel antidepressants. However, the mechanisms underlying burst firing in LHb are not fully understood. The...
N-methyl-D-aspartate receptor (NMDAR) antagonists, including ketamine, phencyclidine (PCP), and dizocilpine (MK-801), are an important class of drugs that can produce antidepressant, hallucinogenic, dissociative, psychotomimetic, and anesthetic effects in humans and animal models. To understand the effects of NMDAR antagonists on the brain, it is essential to map their actions at cellular...
This study explores the role of self-transcendence values in reducing anxiety among Chinese undergraduates, with a particular focus on how self-enhancement values and self-construal styles moderate this relationship. A total of 567 undergraduate students were assessed using the Portrait Values Questionnaire (PVQ-21), the Trait Anxiety Inventory (T-AI), and the Self-Construal Scale (SCS)....
In this paper I attempt to trace the semiotic path of meaning experience from “nothing” into “something”. Traditional communication studies are problematic in 1. focusing on the message to the effect of ignoring the communicators; 2. choosing to overlook how yet-to-be signs acquire meanings in the communicative moments; and 3. tending to assume a “natural science” attitude toward the studied...