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Feng Liang

2 papers in the library · 1 citation · publishing 2025

Papers

NMDA receptor antagonist induced c-Fos expression in the medial entorhinal cortex during postnatal development.

Frontiers in Neural Circuits January 1, 2025 Feng Liang, Hong Wang, Robert Konrad Naumann 1 citation

Injecting the NMDAR antagonist MK-801 into mice produced a 10-fold higher density of c-Fos—a marker of neuronal activity—in the medial entorhinal cortex (MEC) compared to other forebrain regions. c-Fos was concentrated in layer 3 of the dorsal MEC. Parvalbumin (PV)-positive inhibitory neurons showed a spatial correlation with c-Fos: high and medium PV neurons correlated positively with c-Fos density, while low PV neurons correlated negatively. During postnatal development, PV expression appeared on day 12, two days before c-Fos emerged on day 16. The findings suggest that specific subtypes of inhibitory and excitatory neurons in local circuits are critical for sustained neuronal responses to NMDAR antagonists, and that dense PV input may be necessary for inducing c-Fos in MEC principal neurons.

DOI: 10.3389/fncir.2025.1619534 (opens in new tab) Full text (opens in new tab) Mk-801 Nmda receptor antagonist C-fos Entorhinal cortex +1

Ketamine induces delirium-like behavior and interferes with endosomal tau trafficking

Xinghua Ren, Siyi Zhang, Yongyan Yang et al.

Ketamine, an anesthetic and antidepressant, can induce delirium-like behavior in mice and increase tau protein in their blood. In cultured cells, ketamine disrupts endosome function—key organelles for tau release—by increasing endosomal markers Rab5 and Rab7, inhibiting endosome maturation, and boosting tau accumulation in endosomes and the culture medium. These findings suggest ketamine may interfere with tau trafficking, potentially contributing to neurotoxicity and delirium, warranting further research into anesthetic safety.

DOI: 10.21203/rs.3.rs-1362130/v1 (opens in new tab)