NMDA receptors are not necessary for burst firing of lateral habenula neurons in mice.
Frontiers in Psychiatry 2026 Rong Zhou, Jingjing Lu, Yunxiang Ling et al.
Burst firing in the lateral habenula (LHb) is enhanced under stress and depression, and ketamine blocks burst firing in LHb to exert a rapid antidepressant effect. Thus, burst firing in LHb may serve as a cellular mechanism of depression and a promising therapeutic target for developing novel antidepressants. However, the mechanisms underlying burst firing in LHb are not fully understood. The...