PURPOSE Hemophilic arthropathy is a debilitating condition characterized by recurrent hemarthroses, leading to severe joint pain and eventual need for total knee arthroplasty (TKA). Postoperative pain management in this population is highly complex as the result of inherent bleeding risks, intense perioperative anxiety, and a frequently observed "pain-fear-immobility" cycle. The growing need...
Second-generation mindfulness-based interventions (SG-MBIs), which integrate ethical and moral practices, have emerged as promising treatments for depressive and anxiety symptoms. This meta-analysis aims to evaluate the effectiveness of SG-MBIs in reducing depression and anxiety among adults. We conducted a meta-analysis of randomized controlled trials (RCTs) including adults from clinical...
Postpartum depression (PPD) affects 10-20% of women after childbirth, with incidence reaching 30-50% in high-risk populations. Acute postoperative pain and sleep disturbance represent modifiable risk factors. This study evaluated whether a multimodal analgesic protocol combining dexmedetomidine and esketamine is associated with reduced PPD incidence in high-risk parturients undergoing cesarean...