Background Religious and spiritual practices are increasingly recognised as complementary approaches for managing severe mental illnesses, but their use among patients with schizophrenia in China remains poorly understood. Objectives To investigate religious affiliation, religious, spiritual, or folk healing practices, perceived helpfulness, and associated factors among Chinese patients with...
Depression constitutes a major global public health burden, with university students exhibiting a disproportionately high prevalence of depressive symptoms. Although Mindfulness-Based Stress Reduction (MBSR) has demonstrated efficacy in alleviating depressive symptomatology, its underlying neurobiological mechanisms remain incompletely understood. This randomized controlled trial investigated...
Postoperative nausea and vomiting (PONV) are common complications after surgery. Opioid use is a significant risk factor. We utilised a crossover design to test this hypothesis in the same individuals that opioid-free anaesthesia (OFA) compared with opioid-inclusive anaesthesia reduces PONV. This randomised double-blind crossover trial included adult patients undergoing two surgical procedures...
Resilience helps mitigate the negative impacts of stress and promotes effective adaptation in adverse situations. This study investigated the impact of immediate and standardized mindfulness meditation (MM) on the resilience of college students, aiming to offer adaptable MM practices for different stress scenarios. The blood pressure (BP) and heart rate variability (HRV) of 48 participants were...
Emergency endotracheal intubation in critically ill patients are dangerous procedures with a greater risk of severe hypotension The efficacy and safety of esketamine with sympathoexcitatory effects for rapid sequence induction in critically ill patients remain unclear. In this prospective double-blinded randomized controlled trial, adult patients were randomly assigned to receive either...
Multimodal analgesic strategy is pivotal for enhanced recovery after surgery. The objective of this trial was to assess the effect of subanesthetic esketamine vs. placebo combined with erector spinae plane block (ESPB) vs. intercostal nerve block (ICNB) on postoperative recovery following thoracoscopic lung resection. This randomized, controlled, 2×2 factorial trial was conducted at a...
This systematic review investigates the impact of meditation on neural responses to pain, as measured by functional magnetic resonance imaging (fMRI). Up to March 2024, we conducted searches across four databases for human studies implementing fMRI to assess the efficacy of meditation for pain relief. Eighteen studies met the inclusion criteria. Our systematic review indicates that activation...
Depressive symptoms are common among perimenopausal women with breast cancer having modified radical mastectomy. Esketamine exerts antidepressant effects. This study aims to assess whether an intraoperative sub-anesthetic dose of esketamine prevents postoperative depressive symptoms in these patients. In this randomized, triple-blinded, placebo-controlled trial, we will enroll 130...