Comparative genome analysis provides a foundation for defining salvinorin A biosynthesis in Salvia divinorum
Nature Communications March 23, 2026 Haixiu Li, Yuwei Sun, Wenliang Xu et al. 1 citation
The synthesis of salvinorin A by Salvia divinorum is of considerable interest for developing pain relief, anti-opioid addiction and antidepressant medications, but progress has been compromised by limited access to plant material and the complexity of the biosynthetic pathway. Initially using S. splendens, a closely related species, the first steps in the biosynthetic pathway have been...