Cannabidiol exhibits anxiolytic-like effects and antipsychotic-like effects in mice models.
Neuroscience Letters March 1, 2024 Guangzhao Shu, Yang He, Jin Suo et al.
Cannabidiol (CBD), a non-psychoactive compound derived from the cannabis plant, has been confirmed to induce anxiolytic-like and antipsychotic-like effects. However, the exact mechanisms remain unclear. This study substantiated CBD's interaction with the 5-HT1A receptor (5-HT1AR) in vitro (CHO cells expressing human 5-HT1AR) and in vivo (rat lower lip retraction test, LLR test). We then...