Abstract Objectives It has been assumed that decentering is one mechanism underlying the health-promoting benefits of mindfulness. This study aimed to investigate the potential mediating role of decentering in the relationship of mindfulness with psychological problems. Moreover, this study examined whether age and clinical status moderated this relationship. Method This study systematically...
Depression is a common, debilitating mood disorder, but currently available antidepressants have several major drawbacks. Both ketamine and scopolamine attract more and more attention due to their rapid and sustained antidepressant activities. However, the molecular and cellular mechanism that underlies the therapeutic action of ketamine and scopolamine still remain to be elucidated....
Salvinorin A (1), the main active ingredient of Salvia divinorum, is a potent and selective κ opioid receptor (KOPR) agonist. Based on the SAR, its C-2 position is one of the key binding sites and has very little space tolerance (3-4 carbons atoms) and limited to only lipophilic groups. In our attempt to prepare PET brain imaging agent for mapping KOPR, a series of C-2 halogenated analogs have...