Online mindfulness-based interventions (MBIs) delivered via apps or websites significantly improve quality of life, sleep, anxiety, depression, distress, and perceived stress in cancer patients compared to standard care, based on a meta-analysis of 15 randomized controlled trials involving 1,613 participants. No significant effects were found for fear of cancer recurrence or posttraumatic growth. Most interventions were multicomponent, website-based health self-management programs used internationally. The findings suggest online MBIs are promising for mental health and quality of life in oncology, though further research is needed to tailor them to individual symptoms.
In patients undergoing total laparoscopic hysterectomy, a single low dose of esketamine (0.25 mg/kg) given at anesthesia induction did not improve overall quality of recovery as measured by the QoR-40 questionnaire compared to saline. However, esketamine reduced intraoperative opioid use, stabilized blood pressure and heart rate, shortened time to extubation and recovery room stay, and lowered postoperative pain scores, inflammation, and sleep disturbance without causing adverse effects. Higher education level was associated with better recovery.
PCP and similar drugs (MK-801, TCP) increased the firing rate and burst activity of dopamine neurons in the rat ventral tegmental area, converting nonbursty cells to bursty. These effects were dose-dependent and contrast with BTCP, a PCP derivative with little affinity for the PCP binding site, which inhibited firing and decreased bursting. Competitive NMDA antagonists CGS 19755 and (±)CPP did not alter any measured parameters. The findings suggest that the psychotomimetic properties of PCP-like drugs arise from increased dopamine neuron activity and resultant hyperdopaminergia in mesolimbic-mesocortical regions, and that this effect is not due to loss of activity at the NMDA recognition site.