Electrocortical Indices of Default Mode Network-Related Activity in ADHD and Modulation Through Mindfulness-Based Cognitive Therapy.
Brain Topography June 26, 2026 Poppy L A Schoenberg, Reza M Zargar, Sevket Hepark
ADHD involves a dominant Default-Mode Network (DMN) and reduced Task Positive Network (TPN) activity, impairing attention and executive function. Using EEG data from 54 ADHD patients and 16 healthy controls, the study found significantly reduced power across EEG spectra and increased medial ventral prefrontal cortex activation in ADHD patients. A 12-week Mindfulness-Based Cognitive Therapy (MBCT) program, with 30 patients randomly assigned to MBCT and 24 to a wait-list, increased beta power and precuneus activation. These changes may reflect enhanced cortical alertness and more adaptive DMN-TPN regulation, suggesting MBCT's clinical utility and potential neural markers for inattention and executive dysfunction.