Addiction (Abingdon, England)
January 29, 2026
Yi-Hsuan Liu, Chia-Chun Hung, Marc N Potenza et al.
Recreational ketamine use has increased globally and is associated with psychiatric and cognitive concerns. The hippocampus in preclinical models shows damage and working-memory disruption with repeated dosing. However, whether specific hippocampal subregions may differ in people with chronic ketamine use remains unclear. In Taiwan, ketamine is predominantly consumed by smoking ketamine mixed...
EClinicalMedicine
2026
Henrique Nunes Pereira Oliva, Tiago Paiva Prudente, Alisson M Paredes Naveda et al.
5 citations
Sleep disturbances are common in individuals with substance use disorders (SUDs), often persisting beyond initial abstinence and hindering recovery. However, the underlying sleep abnormalities warrant further investigation, particularly given mixed findings regarding specific substances. This systematic review and meta-analysis aimed to identify sleep-related abnormalities associated with...
PNAS Nexus
September 1, 2025
Xin Luo, Huabin Wang, Xuefeng Xu et al.
Internet gaming disorder (IGD) frequently co-occurs with depression. IGD and depression have overlapping and distinct biological and psychological substrates. Mindfulness meditation (MM) has demonstrated efficacy in treating IGD and depression separately. However, its efficacy in treating concurrent IGD and depression and the possible brain mechanisms remain largely unknown. Seventy individuals...
Expert Opinion on Pharmacotherapy
February 1, 2025
Alejandra Pulido-Saavedra, Anna Borelli, Razi Kitaneh et al.
Substance use disorders (SUDs) are a public health issue, with only some having FDA-approved indicated treatments and these having high attrition. Consequently, there has been interest in novel interventions (e.g. psychedelics that target 5-HT2A receptors) with some promising results. In this narrative review, we aim to focus on the role of the 5-HT2A receptors on the effectiveness of the...
JAMA Network Open
June 3, 2024
Haosen Ni, Huabin Wang, Xuefeng Ma et al.
The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR), recently identified internet gaming disorder (IGD) as a condition warranting more research, and few empirically validated treatments exist. Mindfulness meditation (MM) has multiple health benefits; however, its efficacy in treating IGD and potential neural mechanisms underlying MM treatment of...
Frontiers in Psychiatry
June 26, 2023
Simon Zhornitsky, Henrique Nunes Pereira Oliva, Laura A. Jayne et al.
12 citations
Background Ketamine and psychedelics have abuse liability. They can also induce “transformative experiences” where individuals experience enhanced states of awareness. This enhanced awareness can lead to changes in preexisting behavioral patterns which could be beneficial in the treatment of substance use disorders (SUDs). Preclinical and clinical studies suggest that ketamine and psychedelics...
Journal of Behavioral Addictions
December 1, 2019
Clayton H. Mcclintock, Patrick D. Worhunsky, Jiansong Xu et al.
18 citations
Background and aims Spirituality is an important component of 12-step programs for behavioral and substance addictions and has been linked to recovery processes. Understanding the neural correlates of spiritual experiences may help to promote efforts to enhance recovery processes in behavioral addictions. We recently used general linear model (GLM) analyses of functional magnetic resonance...
Cerebral Cortex
May 14, 2018
Lisa Miller, Iris M. Balodis, Clayton H. Mcclintock et al.
65 citations
Across cultures and throughout history, human beings have reported a variety of spiritual experiences and the concomitant perceived sense of union that transcends one's ordinary sense of self. Nevertheless, little is known about the underlying neural mechanisms of spiritual experiences, particularly when examined across different traditions and practices. By adapting an individualized...
Addiction (Abingdon, England)
October 2010
Judson A Brewer, Sarah Bowen, Joseph T Smith et al.
Both depression and substance use disorders represent major global public health concerns and are often co-occurring. Although there are ongoing discoveries regarding the pathophysiology and treatment of each condition, common mechanisms and effective treatments for co-occurring depression and substance abuse remain elusive. Mindfulness training has been shown recently to benefit both...