During the first REM sleep episode of the night, transcranial magnetic stimulation (TMS) triggered widespread and differentiated patterns of cortical activation on electroencephalography (EEG), similar to those observed during wakefulness. In contrast, during NREM sleep, cortical activations became more local and stereotypical, indicating impaired intracortical dialogue. These findings suggest that TMS combined with high-density EEG can probe the internal dialogue of the thalamocortical system, potentially offering a method to assess brain function in patients who are unable to move or communicate.
A survey of 1120 meditators found that most report having had anomalous and extraordinary experiences during meditation, such as mystical, transpersonal, or difficult phenomena. While meditation research has largely focused on clinical effectiveness and neural correlates, these less-studied experiences may be crucial for psychological and spiritual development, act as mediators of meditation's benefits, or be important outcomes themselves. A task force of researchers and teachers developed recommendations to expand research into these areas, which represent largely uncharted scientific terrain suitable for rigorous investigation.