International Journal of Advanced Psychiatric Nursing
2020
M. Baskaran, Saravanan Mani, T. Maheswari et al.
Lysergic acid diethylamide (LSD) is a semisynthetic compound with solid psychoactive properties. Chemically related to serotonin LSD was initially hypothesized to produce a psychosis-like state.1 Afterward, LSD was accounted for to have benefits in the treatment of addictions. However, far reaching unpredictable use and reports of unfriendly impacts brought about the arrangement of LSD as an...
Basic and clinical neuroscience
2020
Nor Suliana Mustafa, Nor Hidayah Abu Bakar, Nasir Mohamad et al.
N-Methyl-3, 4-methylenedioxyamphetamine (MDMA), or ecstasy is a recreational drug of abuse. It is a synthetic substance that affects the body's systems, which its mechanism of action and treatment should be more investigated. MDMA provides an immediate enjoyable feeling by stimulating the release of neurotransmitters, such as dopamine and serotonin in the brain. Unfortunately, abnormal...
2020
Charles D. Nichols, P. Hendricks
Abstract Recently, there has been a resurgence of interest in the study of classic serotonergic hallucinogens, now widely referred to as classic psychedelics. These studies include fundamental molecular and cellular neuroscience and pharmacology, neuroimaging, and psychological experiments. In the early days of classic psychedelic research during the 1950s through the 1970s, classic...
edoc (University of Basel)
2020
Patrick Vizeli
Psychoactive substances such as the ring substituted phenylethylamine 3,4-methylenedioxymethamphetamine (MDMA; “ecstasy”) are widely used in recreational settings. Additionally, recent research highlights substance-assisted psychotherapy as potential new effective treatment for various psychiatric disorders, e.g. post-traumatic stress disorder (PTSD). MDMA releases and inhibits the uptake of...
Absolute Addiction Psychiatry Review
2020
Mashal Khan, Anil A. Thomas
3 citations
Anabolic-androgenic steroids, inhalants, hallucinogens, dissociative anesthetics and “club drugs” are a heterogeneous group of substances that have considerable potential for misuse and associated morbidity and/or mortality. Steroid use often goes undetected, even by addiction psychiatrists, though significant medical and psychiatric consequences often arise from chronic use. Inhalants, which...
Common Library Network (Der Gemeinsame Bibliotheksverbund)
2020
Janis Fricke
In der gegenwärtigen Arbeit wurden die Strukturvielfalt und die genetischen und enzymatischen Grundlagen der Indolalkaloidbiosynthese in Basidiomyceten in Psilocybe spp. untersucht. Durch in silico-Analysen und heterologe Expression ist es gelungen, die Biosynthese des Psilocybins aufzuklären, die verantwortlichen Gene zu identifizieren und die resultierenden Enzyme biochemisch und...
Psychopharmacology
December 18, 2019
Neiloufar Family, Émeline L. Maillet, Luke T. J. Williams et al.
142 citations
Abstract Abstract Research has shown that psychedelics, such as lysergic acid diethylamide (LSD), have profound anti-inflammatory properties mediated by 5-HT 2A receptor signaling, supporting their evaluation as a therapeutic for neuroinflammation associated with neurodegenerative disease. Objective This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of orally...
Current Psychopharmacology
December 13, 2019
Rashmi S. Pal, Nikita Saraswat, Pranay Wal et al.
Background: Depression is the neuropsychiatric disorder that can lead to the disruption of brain nerves by elevating different mechanisms and neurotransmitters such as serotonin, noradrenaline, dopamine. It can have a series of episodic events that can cross one episodic depression to another and manifest various symptoms such as agitation, melancholia, deep sadness, psychomotor retardation,...
December 13, 2019
Vítor Bruno
1 citation
\n Alucinógenos (ALU) são substâncias psicoativas que não induzem o indivíduo à dependência, possuem perfil de segurança de uso mais alto quando comparado a outras drogas e baixa capacidade de causar tolerância ao uso. Estudos recentes propõem o uso de ALU como tratamento a algumas doenças e transtornos relacionados ao sistema nervoso central, como a depressão, ansiedade e dependência. Dentre...
International Journal of Environmental Research and Public Health
December 12, 2019
Patricia P Wadowski, Georgiana-Aura Giurgea, Oliver Schlager et al.
Objective: N-(2-methoxy) benzyl-phenethylamine (NBOMe) derivatives have a high affinity to the serotonin receptor 2A and emerged as new psychedelic agents. We report the case of a 30-year-old man admitted to the hospital because of acute ischemia of the left arm with clinical symptoms of pallor, pulselessness, paresthesia, and a motoric deficit. The patient had a history of schizophrenia and...