edoc (University of Basel)
2020
Patrick Vizeli
Psychoactive substances such as the ring substituted phenylethylamine 3,4-methylenedioxymethamphetamine (MDMA; “ecstasy”) are widely used in recreational settings. Additionally, recent research highlights substance-assisted psychotherapy as potential new effective treatment for various psychiatric disorders, e.g. post-traumatic stress disorder (PTSD). MDMA releases and inhibits the uptake of...
edoc (University of Basel)
2018
Katharina Beck, Erich Studerus, Anita Riecher‐rössler
Cannabis ist neben Nikotin und Alkohol eine der am häufigsten psychotropen Substanzen weltweit. Welche Auswirkungen hat regelmässiger Cannabis-Konsum auf die Wahrscheinlichkeit an einer Psychose zu erkranken? Wie wirkt er sich aus bei Personen mit einer Prädisposition oder bei bereits Erkrankten?
edoc (University of Basel)
2018
Dino Lüthi
Since the mid-2000s, an unprecedented amount of new psychoactive substances (NPSs) have emerged on the recreational drug market and have since then gained popularity as alternatives to traditional drugs of abuse. Besides clinical case reports, the pharmacological profiling and assessment of toxicity in vitro provide valuable information on the mechanism of action and possible risks associated...
edoc (University of Basel)
2017
Patrick C. Dolder
1 citation
My PhD thesis consisted of two different scientific parts, each supervised by one of my advisors, Prof. Dr. med. Matthias Liechti and Prof. Dr. sc. nat. Katharina Rentsch. One part was to develop liquid chromatography tandem mass spectrometry (LC-MS/MS) methods to measure d-lysergic acid diethylamide (LSD) and its main metabolites in plasma, serum, and urine samples. We established the...
edoc (University of Basel)
2016
Anna Rickli
1 citation
This PhD work consists of an in vitro and in vivo part. In the in vivo part, we investigated the role of dopamine in the acute clinical effects of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) in healthy human subjects. The role of dopamine in the addictive effects of drug of abuse is well established, but whether it contributes to the acute psychotropic effects of MDMA is unclear. \nIn...
edoc (University of Basel)
2013
Cédric M. Hysek
The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is a widely used recreational drug, which produces strong psychological effects such as increased empathy and sociability. MDMA inhibits the uptake of and releases serotonin, dopamine, and norepinephrine via an interaction with the respective monoamine transporter. While the role of serotonin in the human pharmacology...
edoc (University of Basel)
2011
Sarah L Chellappa
This thesis deals with the electrophysiological correlates of sleep prior to dream recall and the age-related effects on dream processing. The dual NREM/REM sleep cycle and the circadian modulation of REM sleep sum to generate dream processing. However, little is known about the age-related effects on dream recall during both NREM and REM sleep, which comprises the first aim of this thesis. To...