Brain research. Developmental brain research
February 8, 2005
Laurent Galineau, Catherine Belzung, Ercem Kodas et al.
We investigated several aspects of the dopaminergic and serotonergic functions throughout brain development in rats prenatally exposed to MDMA ("ecstasy"). Pregnant rats were treated with MDMA (10 mg/kg s.c.) or saline from the 13th to the 20th day of gestation and studies were conducted on the progeny from both groups: (i) quantification of whole brain contents of DA, 5-HT and metabolites from...
Neuropsychopharmacology
January 26, 2005
Olivia Carter, John D. Pettigrew, Felix Hasler et al.
122 citations
Binocular rivalry occurs when different images are presented simultaneously to corresponding points within the left and right eyes. Under these conditions, the observer's perception will alternate between the two perceptual alternatives. Motivated by the reported link between the rate of perceptual alternations, symptoms of psychosis and an incidental observation that the rhythmicity of...
British Journal of Pharmacology
2005
Isabel Escobedo, Esther O’shea, Laura Orío et al.
68 citations
This study investigated whether the immediate and long‐term effects of 3,4‐methylenedioxymethamphetamine (MDMA) on monoamines in mouse brain are due to the parent compound and the possible contribution of a major reactive metabolite, 3,4‐dihydroxymethamphetamine (HHMA), to these changes. The acute effect of each compound on rectal temperature was also determined. MDMA given i.p. (30 mg kg −1 ,...
Developmental Psychobiology
2005
Brian J. Piper, Joseph B. Fraiman, Jerrold S. Meyer
71 citations
Previous research in our laboratory found that repeated exposure of adolescent rats to 3,4-methylenedioxymethamphetamine (MDMA) impaired working memory and reduced anxiety. The present experiment extended these findings by investigating the physiological, behavioral, and neurotoxic effects of a modified MDMA treatment regimen. Male Sprague-Dawley rats received 5 mg/kg of MDMA hourly for a...
Synapse
2005
Luciano Minuzzi, George G. Nomikos, Mark Wade et al.
25 citations
The psychoactive properties of the hallucinogen LSD have frequently been attributed to high affinity interactions with serotonin 5HT2 receptors in brain. Possible effects of LSD on dopamine D2/3 receptor availability have not previously been investigated in living brain. Therefore, we used PET to map the binding potential (pB) of [11C]raclopride in brain of three pigs, first in a baseline...
2005
Niels Jensen
8 citations
Aeruginascin ist ein Naturstoff aus dem halluzinogenen Pilz Inocybe aeruginascens. Die Substanz wurde isoliert und als 4-Phosphoryloxy-N,N,N-trimethyl-tryptamin identifiziert. Aeruginascin ist das quartäre Trimethylammonium-Analogon der halluzinogenen Substanz Psilocybin. Synthetisches Aeruginascin war in allen Aspekten identisch mit der isolierten Probe. Zusätzlich wurden die Pilzalkaloide...