Psychedelic-assisted psychotherapy has demonstrated efficacy in treating individual mental health conditions such as addiction, anxiety, depression, and post-traumatic stress disorder. However, current research predominantly focuses on individual experiences, overlooking the relational and systemic factors that influence healing and long-term therapeutic outcomes. This conceptual article...
Os transtornos psiquiátricos representam importante problema de saúde pública mundial, frequentemente associados a elevada morbidade, incapacidade funcional e impacto significativo na qualidade de vida. Apesar dos avanços terapêuticos disponíveis, muitos pacientes permanecem refratários aos tratamentos convencionais, estimulando a busca por novas abordagens terapêuticas. Nesse contexto, os...
Trauma-related distress in adult women often extends beyond posttraumatic stress disorder (PTSD) to include depressive symptoms and dissociation, yet the roles of mindfulness and self-compassion across these symptom domains remain insufficiently clarified. This study examined mindfulness and self-compassion as psychological resources associated with trauma-related symptoms among trauma-exposed...
Background. The perception of internal bodily states (interoception) serves as a fundamental mechanism of traumatic experience. In clinical practice, this experience often remains unarticulated and phenomenologically inaccessible due to a deficit in the skill of tacting private events. This creates a fundamental obstacle to the integration of traumatic experience within Trauma-Focused...
Background: Depression and anxiety are common mental health problems that frequently co-occur with trauma-related disorders and often develop following traumatic or stressful events, substantially impairing quality of life. Mindfulness-based interventions have been shown to reduce these symptoms; however, their widespread implementation is often limited by poor accessibility and low adherence....
This chapter examines how psychoactive substances shape hallucinations by acting on perception, prediction and meaning-making rather than “creating” experiences from nothing. It contrasts the hallucinatory styles of classic psychedelics, stimulants and dissociative drugs, linking their neurochemical effects to characteristic changes in vision, sound, body experience and selfhood. The discussion...
This chapter is designed to offer a comprehensive overview of five core psychedelic medicines—ketamine, psilocybin, MDMA, LSD, and ayahuasca—highlighting their distinct pharmacological properties, cultural origins, therapeutic applications, and clinical research. Although each substance offers a unique entry point into expanded states of consciousness, they share a common potential to catalyze...
Emerging research in contemplative science and psychedelic neuroscience suggests that deeply entrenched patterns of selfhood and cognition—often associated with mental disorders like depression—can be profoundly altered through both meditative practice and pharmacological intervention. This paper presents a neuroconstructivist framework for understanding how deep meditation and dissociative...
Zusammenfassung Die Psychedelika-assistierte Therapie (PAT) hat sich in den letzten Jahren zu einem der dynamischsten Forschungsfelder der Psychiatrie entwickelt. Während die beste Evidenz bisher für depressive Störungen und posttraumatische Belastungsstörungen vorliegt, wird PAT zunehmend auch bei anderen nicht-psychotischen Störungen untersucht. Jenseits der Symptomlinderung rückt die...
NeuropsychopharmacologyMay 9, 2026Ana Maria Raymundi, Nathalie Carla Cardoso, Gabriel Costa Lourenço et al.
In PTSD, microglia are more engaged in fear-related circuits, where they participate in fear memory processing responses. The reconsolidation-impairing effect of Δ⁹-tetrahydrocannabinol (THC), the primary psychoactive constituent of Cannabis, is typically linked to cannabinoid type-1 receptor (CB1) signaling. THC also engages peroxisome proliferator-activated receptor gamma (PPARγ), and both...