Psilocybin is a chemical compound found in certain types of hallucinogenic mushrooms, known as magic mushrooms. Evidence has shown potential therapeutic effects of psilocybin on different neuropsychiatric disorders such as major depressive disorder (MDD), posttraumatic stress disorder (PTSD), anxiety disorders, and obsessive-compulsive disorder (OCD). Although the efficacy of psilocybin in...
Ketamine, a non-competitive N-Methyl-D-Aspartate receptor antagonist, was approved for use with Treatment-Resistant Depression (TRD) and is currently in clinical trials for treating substance use disorder (SUD), and Post Traumatic Stress Disorder. However, ketamine is an addictive drug, and thus we need to better understand ketamine's mechanism of action in addiction to reliably assess the...
Psilocybin has demonstrated promise for improving depressive symptoms in treatment-resistant depression, but its effects on anxiety, quality of life, functioning, and posttraumatic stress symptoms are less well studied. This study reports exploratory findings from an open-label trial in Veterans with TRD. Participants received a single 25-mg dose of psilocybin administered with psychological...
Introduction Previous studies have shown that self-disturbances mediate the relationship between traumatic life events and psychotic-like experiences. However, it is unknown whether this model may be extended to stress sensitivity. We hypothesize that a history of early trauma increases the risk for psychotic experiences through stress sensitization and disturbance of the basic sense of self....
Aims: Recreational ketamine use and treatment-seeking for associated complications is increasing in England. Complications of ketamine dependence can be debilitating, leading to continued dependence and surgical intervention. However, treatment remains under-researched, with lacking understanding of those seeking treatment or requiring specialist inpatient detoxification. This study aims to...
Introduction Dissociative fugue is a rare condition, falling within the spectrum of dissociative identity disorders as per the DSM-V criteria. This condition is marked by an abrupt and unforeseen departure from one’s usual routine, accompanied by memory lapses. Its occurrence within the general population is estimated at a mere 0.2%, and individuals may linger in this fugue state for a few days...
European PsychiatryJune 1, 2026V. Fournier, André Kuntz, Rafik Bouzegaou et al.
Introduction As the number of treatment resistant patient in the psychiatric field has been growing over the last decades, there is a clear need for new therapeutic options. Over several years, the field of psychedelic assisted psychotherapy has been rapidly developing. In this scope ketamine assisted psychotherapy (KAP) has come into psychiatric use to treat depression resistant depression,...
Introduction MDMA (3,4-methylenedioxymethamphetamine)–assisted therapy has gained growing scientific attention as a potential treatment for post-traumatic stress disorder and other mental health conditions. Although clinical studies suggest potential benefits, concerns remain regarding cardiovascular safety, methodological rigor, and variability in psychotherapeutic support (Singh et al . CNS...
Chronic pain with psychological comorbidity, especially posttraumatic stress disorder (PTSD) and/or depression, is a prevalent and costly problem, especially among Veterans. Compassion meditation (CM) is a meditative practice that focuses on developing attentional regulation and the intention to assuage suffering. CM-based approaches show promise in ameliorating physical and mental health...
This paper explores the integration of classical yogic practices as a holistic intervention for mental health within the contemporary clinical landscape. Anchored in Patanjali’s foundational definition of Yoga as chitta-vritti-nirodha (the cessation of the fluctuations of consciousness), the study examines how the ancient “Eight Limbs” framework addresses modern psychological pathologies,...