Nature MedicineSeptember 2026Stefan Roepke, Nikola Schoofs, Kathlen Priebe et al.
Nightmares are a hallmark of post-traumatic stress disorder (PTSD), yet pharmacological treatments remain limited. Here we conducted a multicenter, double-blind, randomized, placebo-controlled trial to evaluate the efficacy and safety of dronabinol (BX-1; Δ9-tetrahydrocannabinol (THC)) for PTSD-related nightmares. Adults with PTSD and recurrent nightmares were randomly assigned to receive...
Aim: To evaluate the effectiveness of mindfulness-based interventions among nurses. Background: The demanding workload and high emotional investment inherent in nursing practice render nurses vulnerable to compassion fatigue, job burnout, and traumatic stress. Methods: A systematic literature search was conducted across major English and Chinese electronic databases. Eligibility criteria were...
Abstract Objectives Nonattachment, defined as the capacity to relate to internal experiences, identities, and external circumstances without clinging, avoidance, or over-identification, has been associated with reduced psychological distress and enhanced well-being, yet its deliberate cultivation within trauma-focused interventions remains underexplored. This study evaluated Nonattachment for...
Psychedelic-assisted therapy has emerged as a prominent area for psychiatric investigation particularly with regards to treatment-resistant depression and Post Traumatic Stress Disorder (PTSD). The purpose of this narrative review was to outline the current body of research regarding psychedelic and psychedelic-like compounds in these two psychiatric conditions highlighting psilocybin-assisted...
Exposure to traumatic events such as disasters, violence, and wars through social media has been associated with psychological distress and secondary traumatic stress (STS). However, limited evidence exists regarding how mindfulness and social sensitivity are associated with this digital form of trauma. This study examined the relationships among mindfulness, social sensitivity, and STS among...
Black adults in the United States navigate profound and often invisible stressors at the intersection of racism and trauma. The burden of chronic racial stress functions as an embodied form of oppression that may increase the risk and intensity of post-traumatic stress disorder (PTSD) symptoms and undermine psychological strengths such as mindfulness and self-compassion for healing, recovery,...
Abstract Major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) are prevalent, chronic, and disabling mental health conditions which are difficult to treat. Ketamine has demonstrated effect for improving depression and PTSD symptoms independently but reports often overlook focused comorbid improvement of these symptoms within individuals. To address this, we assessed...
Abstract Post-traumatic stress disorder (PTSD) is a highly prevalent, debilitating psychiatric condition. Existing treatments are ineffective for many patients. 3,4- methylenedioxymethamphetamine (MDMA)-assisted psychotherapy has demonstrated substantial clinical efficacy but relies on prolonged, resource-intensive therapeutic protocols that limit scalability and accessibility. Here, we...
Post-traumatic stress disorder places patients at risk for emergence agitation following surgical procedures under general anaesthesia. Gynaecological procedures, sphincteroplasty, and surgical interventions involving the pelvic floor can involve vulnerable patient positioning in theatre, with inserted catheters and sensory stimulation. Such interventions could contribute to postoperative...