Psychotropes
April 23, 2018
Christian Sueur
3 citations
L’utilisation thérapeutique des substances psychédéliques a été concomitante de la découverte du LSD et de la Mescaline après la Seconde Guerre mondiale. Ces utilisations thérapeutiques concernaient, à l’origine, essentiellement « l’accompagnement » des psychothérapies (thérapies psycholytiques), le traitement des addictions (alcool, puis opiacés) et, du fait de leurs capacités anxiolytiques et...
ACS Chemical Neuroscience
April 17, 2018
Lindsay P. Cameron, Charlie J. Benson, Lee E. Dunlap et al.
168 citations
Depression and anxiety disorders are debilitating diseases resulting in substantial economic costs to society. Traditional antidepressants often take weeks to months to positively affect mood and are ineffective for about 30% of the population. Alternatives, such as ketamine, a dissociative anesthetic capable of producing hallucinations, and the psychoactive tisane ayahuasca, have shown great...
Frontiers in Pharmacology
April 5, 2018
Antonio Inserra
91 citations
Ayahuasca ingestion modulates brain activity, neurotransmission, gene expression and epigenetic regulation. N,N-Dimethyltryptamine (DMT, one of the alkaloids in Ayahuasca) activates sigma 1 receptor (SIGMAR1) and others. SIGMAR1 is a multi-faceted stress-responsive receptor which promotes cell survival, neuroprotection, neuroplasticity, and neuroimmunomodulation. Simultaneously, monoamine...
Sleep
April 1, 2018
Sooyeon Aly Suh, J Kim, S Han et al.
1 citation
Imagery Rehearsal Therapy(IRT) is relatively a new evidence-based treatment for nightmare disorder patients. This is the first time investigating the treatment effects of IRT using fMRI. Based on past studies by Shen et al.(2016), nightmare disorder patients show increased regional homogeneity in both the anterior cingulate and inferior parietal lobule. This study used a one group pre-post...
Brain Imaging and Behavior
March 17, 2018
Jonathan Greenberg, Victoria Romero, Seth Elkin-Frankston et al.
69 citations
Proactive interference occurs when previously relevant information interferes with retaining newer material. Overcoming proactive interference has been linked to the hippocampus and deemed critical for cognitive functioning. However, little is known about whether and how this ability can be improved or about the neural correlates of such improvement. Mindfulness training emphasizes focusing on...
Military Medicine
March 1, 2018
Paul N Kizakevich, Randall Eckhoff, Janice Brown et al.
Post-traumatic stress and other problems often occur after combat, deployment, and other military operations. Because techniques such as mindfulness meditation show efficacy in improving mental health, our team developed a mobile application (app) for individuals in the armed forces with subclinical psychological problems as secondary prevention of more significant disease. Based on the...
Anthropology of Consciousness
March 1, 2018
Yochai Ataria
Abstract: The traumatic experience and the meditative experience differ in many respects. For instance, it is possible to suggest that while a sense of helplessness is the most important feature of the traumatic experience, meditation does not involve a similar sense of helplessness. Furthermore, while trauma is shocking and horrifying, meditation is considered to be constructive and efficient...
Neuropharmacology
February 21, 2018
Sean J Belouin, Jack E Henningfield
189 citations
The purpose of this commentary is to provide an introduction to this special issue of Neuropharmacology with a historical perspective of psychedelic drug research, their use in psychiatric disorders, research-restricting regulatory controls, and their recent emergence as potential breakthrough therapies for several brain-related disorders. It begins with the discovery of lysergic acid...
Psychopharmacology
February 1, 2018
Liana Fattore, Alessandro Piva, Mary Tresa Zanda et al.
Clinical data with 3,4-methylenedioxymethamphetamine (MDMA) in post-traumatic stress disorder (PTSD) patients recently stimulated interest on the potential therapeutic use of psychedelics in disorders characterized by maladaptive memories, including substance use disorders (SUD). The rationale for the use of MDMA in PTSD and SUD is being extended to a broader beneficial "psychedelic effect,"...
Frontiers in Psychiatry
2018
Christina W. Slotema, Jan Dirk Blom, Marieke B A Niemantsverdriet et al.
Background: Auditory verbal hallucinations (AVH) are experienced more frequently by patients with borderline personality disorder (BPD) than previously assumed. However, consensus is lacking on how to treat them. Objective: To provide a systematic review of studies reporting on AVH in patients with BPD, with a focus on the efficacy of treatment of psychotic symptoms. Methods: For this review a...