Trauma-related autobiographical memories can manifest as involuntary, vivid, emotionally charged intrusions that perpetuate avoidance, negative emotions, and functional impairment. While these memories are central to post-traumatic stress disorder (PTSD), they also occur across diagnoses and are often reported in depressive disorders, including treatment-resistant depression (TRD). Although...
Recent clinical evidence suggests that racemic 3,4-methylenedioxymethamphetamine (MDMA) might be useful for treating a range of neuropsychiatric diseases including post-traumatic stress disorder (PTSD) and depression. However, concerns about its abuse potential stemming from its monoamine releasing properties have hampered its clinical development. Thus, safer analogues of racemic MDMA with...
Background: Post-traumatic stress disorder often leads to ongoing sleep difficulties such as insomnia and nightmares, which can interfere with mood, concentration, and daily activities. Guided imagery, a relaxation method that uses calming, multisensory visualizations, has shown potential to improve sleep and reduce distress in people experiencing high stress or trauma. This study evaluates the...
Abstract Introduction Targeted Dream Incubation (TDI) is the process of giving an individual auditory cues (i.e., “think of a tree”) while they are falling asleep, with the goal of shaping dream content (into something such as a tree). Recent research has demonstrated TDI may be able to increase dream self-efficacy (DSE) and influence other mental health outcomes. Thus, our study explored how...
SleepMay 1, 2026Holland Doise, A. Gonzalez Quesada, Garrett Baber et al.
Abstract Introduction Nightmares are associated with more severe posttraumatic stress disorder (PTSD). The advent of large language models (LLM) offers unique advantages to efficiently code affective dream content over human methods, which can be resource intensive and prone to error. This study tested whether dream affect (DA), measured via self-report, human-rated narrative coding, and LLM...
Trauma-related dissociation can present with derealisation, depersonalisation, abrupt lapses in awareness, memory gaps, and fugue-like states, and it may be difficult to treat with standard approaches alone. Glutamatergic interventions have been proposed as neuroplasticity-focused strategies because N-methyl-D-aspartate (NMDA) receptor antagonism and downstream...
The phase 2 data presented here support the development of TSND-201 for posttraumatic stress disorder (PTSD), a disorder for which there is a significant unmet need for rapid-acting and effective treatments. TSND-201 (methylone) is a highly selective, rapid-acting neuroplastogen that releases serotonin, norepinephrine, and dopamine without direct activity at 5-hydroxytryptamine (5-HT) 2A...
Four weekly doses of TSND‐201 (methylone), an analog of 3,4 methylenedioxymethamphetamine (MDMA), resulted in significant improvement relative to placebo in reducing symptoms of post‐traumatic stress disorder (PTSD), a Phase 2 study has found. Treatment‐emergent adverse events associated with TSND‐201 were generally mild to moderate in severity, with no significant suicidal ideation. Study...
When assessing sleep disturbances in PTSD, count disturbed awakenings as nightmares at baseline. This is a key symptom of PTSD-related sleep problems and a target for treatment. Investigate nicotine withdrawal in pack-a-day smokers who awaken after several hours. An important indicator is the patient’s ability to return to sleep after smoking a cigarette. For sleep terrors with thrashing and...
Scientific ReportsApril 25, 2026Audrey G. Evers, Elizabeth C. Stade, Aadesh Salecha et al.1 citation
Enthusiastic media coverage of psychedelics as a treatment for mental health disorders is perceived as hyped compared to coverage of established treatments. To measure potential hype, we conducted pre-registered analyses comparing media coverage (e.g., newspaper articles) of psychedelics to FDA-approved antidepressants for major depressive disorder and posttraumatic stress disorder. We used...
Introduction. Following the full-scale Russian invasion of Ukraine, there has been a substantial increase in the need for accessible, rapid-acting, and non-pharmacological approaches to alleviate symptoms of post-traumatic stress disorder and depression among Ukrainian refugees. One potentially useful intervention is the Transcendental Meditation program. Aim. To assess the effectiveness of the...
TrialsApril 13, 2026Fanshan Huang, Weiwei Wang, Xin Miao et al.
Traumatic amputations are common traumatic injuries that require digital replantation to restore the form, function, and sensation of the hand. The post-surgical survival of replanted digits is influenced by multiple factors, including psychological factors such as posttraumatic stress disorder (PTSD), anxiety, and depression. Mindfulness-based cognitive therapy (MBCT) is considered a potential...
L'EncephaleApril 7, 2026Déborah Eymond, Alyson Miquel, Anais Duffaud et al.
Military personnel are frequently exposed to traumatic situations that can lead to chronic post-traumatic stress disorder (PTSD). PTSD complicates their reintegration due to the high risk of retraumatization. To support the reintegration of injured servicemen and women, the army has developed the Omega program which includes courses at the Centre des Blessés de l'Armée de Terre (CReBAT). These...
Psychedelic-assisted therapy for PTSD tends to produce mild, transient adverse effects, but concerns about long-term safety and inconsistent reporting of adverse events highlight the need for further research.
Post-traumatic stress disorder (PTSD) is a chronic mental illness that occurs following exposure to traumatic stressors such as combat, disasters, or assault. It is characterized by a triad of reexperiencing of the trauma, avoidance of triggers for such recollections, and increased vigilance towards threats (1). In 1992, Judith Herman described a variant of PTSD that occurred in persons who had...
Background: Posttraumatic stress disorder (PTSD) is a severe and frequent affection that is highly comorbid to major depressive disorder. Comorbid PTSD and depression increase the risk of treatment-resistant depression (TRD), with a high risk of functional impairment and suicide. Esketamine nasal spray is a recent validated treatment for TRD, but its efficacy on comorbid TRD-PTSD remains...
This study aimed to reduce post-traumatic stress disorder (PTSD) levels in survivors of domestic violence (DV) through a mindfulness-based intervention program modified from Brief Mindfulness-Based Stress Reduction (BMBSR) and Mindfulness-Based Distress Management Training. Seven female DV survivors were involved in the program, which consisted of six meetings over three weeks. The participants...
As a genre, supernatural teen television often engages with complex psychological themes pertaining to adolescents and their lives. One such show is MTV’s Teen Wolf (2011), centered around Scott McCall, a teenager coming to terms with his recent transformation into a werewolf. Teen Wolf, specifically Season Three, Part Two, exhibits these aspects, focusing on trauma using the background of...
Medicine AdvancesMarch 27, 2026Thomas Edward Cutting, Richard Evans Hartman
ABSTRACT Numerous studies have demonstrated the efficacy of (R, S)‐ketamine as a treatment for post‐traumatic stress disorder (PTSD), treatment‐resistant depression, and comorbid occurrences of these conditions. The (R) and (S) stereoisomers of ketamine have also demonstrated efficacy in attenuating stress and depressive symptoms, with (R)‐ketamine demonstrating reduced abuse potential and side...
3,4-methylenedioxymethamphetamine (MDMA) has emerged as a potential treatment for post-traumatic stress disorder (PTSD), generating considerable enthusiasm in the field. However, rapidly changing evidence in a fast-moving field can be challenging to integrate. Here, we present a living systematic review and open-data meta-analytic resource on MDMA treatment for PTSD. In this initial release,...