Traumatic memories that are resistant to modification or extinction are a characteristic feature of post-traumatic stress disorder (PTSD). The process of fear memory reconsolidation has been identified as a potential therapeutic target for the treatment of PTSD. Ketamine, an NMDA receptor antagonist with dissociative properties, has been identified as a drug with high therapeutic potential for...
Abstract Post‐traumatic stress disorder (PTSD) is a debilitating disorder with limited pharmaceutical treatment options. Ketamine, a noncompetitive N ‐methyl‐ d ‐aspartate (NMDA) receptor antagonist with rapid‐onset effects, has emerged as a potential treatment, particularly for patients who do not respond to first‐line therapies. This systematic review synthesizes the current evidence on the...
Pain ManagementOctober 1, 2026Steven Paul Cohen, Roman Smolynets, Jordan Wood et al.
BACKGROUND: Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are conditions that share common mechanisms and are highly co-prevalent with each other and chronic pain. This pragmatic study will compare ketamine infusions to stellate ganglion blocks (SGB), their combination, and a placebo-sham-controlled arm. METHODS: A double-blind study conducted at 3 U.S. and Ukrainian...
A substantial proportion of patients with posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) do not respond to first-line treatment. Approximately 40% of PTSD patients do not respond to first-line psychotherapy, and 30.9% of MDD patients meet criteria for treatment-resistant depression. Yet standard polysomnography in these patients frequently shows REM sleep that appears...
Objective: Posttraumatic stress disorder (PTSD) guidelines are often applied to complex PTSD (CPTSD), despite CPTSD’s distinct symptomatology. Core CPTSD symptoms, including affect dysregulation, negative self-concept, and relational disruption, may substantially alter treatment needs and safety considerations for mindfulness-based interventions. This article discusses clinical considerations...
Background: Mothers are often identified as the primary caregiver, thus at unique risk for psychological sequelae of their child’s cancer, including elevated posttraumatic stress symptoms (PTSS). Studies have shown greater mindfulness is often associated with lower PTSS across populations. Methods: The current study examined associations between mothers’ mindfulness and its specific domains and...
Background: The 7 October 2023 attack in southern Israel was one of the deadliest terror attacks in modern history, with 1,182 fatalities, more than 4,000 wounded individuals, and 251 hostages. The Nova music festival, an all-night outdoor rave near the Gaza border, suffered the highest number of civilian casualties, with more than 370 festival attendees killed. Survivors were exposed to...
Over the past five years, the literature on the psychiatric use of psychedelic and related treatments has expanded substantially. Several randomized controlled trials and pooled analyses have been conducted in mood disorders, treatment-resistant depression, and post-traumatic stress disorder. Trial methodology, however, remains a fundamental source of uncertainty, and despite the popularity of...
Background 3,4-Methylenedioxymethamphetamine (MDMA) is associated with distinctive prosocial and empathogenic effects, yet the consistency and scope of its impact on social cognition in humans remain unclear. Although numerous placebo-controlled studies have examined MDMA’s acute social effects, findings vary widely across subjective and behavioural domains. Methods We conducted a systematic...
There is a need for new effective treatment options for posttraumatic stress disorder (PTSD), as many people with PTSD do not fully recover despite current treatments. 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy (MDMA-AT) is emerging as a new treatment option. We assessed the current body of MDMA-AT evidence for effectiveness in treating PTSD, associated impairments, and...
Healing together: Results from a pilot trial of 3,4-Methylenedioxymethamphetamine-enhanced cognitive-behavioral conjoint therapy for posttraumatic stress disorder.
Nature MedicineSeptember 2026Stefan Roepke, Nikola Schoofs, Kathlen Priebe et al.
Nightmares are a hallmark of post-traumatic stress disorder (PTSD), yet pharmacological treatments remain limited. Here we conducted a multicenter, double-blind, randomized, placebo-controlled trial to evaluate the efficacy and safety of dronabinol (BX-1; Δ9-tetrahydrocannabinol (THC)) for PTSD-related nightmares. Adults with PTSD and recurrent nightmares were randomly assigned to receive...
Aim: To evaluate the effectiveness of mindfulness-based interventions among nurses. Background: The demanding workload and high emotional investment inherent in nursing practice render nurses vulnerable to compassion fatigue, job burnout, and traumatic stress. Methods: A systematic literature search was conducted across major English and Chinese electronic databases. Eligibility criteria were...
Abstract Objectives Nonattachment, defined as the capacity to relate to internal experiences, identities, and external circumstances without clinging, avoidance, or over-identification, has been associated with reduced psychological distress and enhanced well-being, yet its deliberate cultivation within trauma-focused interventions remains underexplored. This study evaluated Nonattachment for...
Psychedelic-assisted therapy has emerged as a prominent area for psychiatric investigation particularly with regards to treatment-resistant depression and Post Traumatic Stress Disorder (PTSD). The purpose of this narrative review was to outline the current body of research regarding psychedelic and psychedelic-like compounds in these two psychiatric conditions highlighting psilocybin-assisted...
Exposure to traumatic events such as disasters, violence, and wars through social media has been associated with psychological distress and secondary traumatic stress (STS). However, limited evidence exists regarding how mindfulness and social sensitivity are associated with this digital form of trauma. This study examined the relationships among mindfulness, social sensitivity, and STS among...
Black adults in the United States navigate profound and often invisible stressors at the intersection of racism and trauma. The burden of chronic racial stress functions as an embodied form of oppression that may increase the risk and intensity of post-traumatic stress disorder (PTSD) symptoms and undermine psychological strengths such as mindfulness and self-compassion for healing, recovery,...
Abstract Major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) are prevalent, chronic, and disabling mental health conditions which are difficult to treat. Ketamine has demonstrated effect for improving depression and PTSD symptoms independently but reports often overlook focused comorbid improvement of these symptoms within individuals. To address this, we assessed...
Abstract Post-traumatic stress disorder (PTSD) is a highly prevalent, debilitating psychiatric condition. Existing treatments are ineffective for many patients. 3,4- methylenedioxymethamphetamine (MDMA)-assisted psychotherapy has demonstrated substantial clinical efficacy but relies on prolonged, resource-intensive therapeutic protocols that limit scalability and accessibility. Here, we...