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Healing together: Results from a pilot trial of 3,4-Methylenedioxymethamphetamine-enhanced cognitive-behavioral conjoint therapy for posttraumatic stress disorder.

Journal of Traumatic Stress September 4, 2026 DOI: 10.1002/jts.70126 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Pilot trial Pilot study Peer reviewed
Population Couples in which one partner has posttraumatic stress disorder
Interventions 3 4-Methylenedioxymethamphetamine Cognitive-behavioral conjoint therapy
Topics MDMA PTSD
Key findings MDMA-enhanced cognitive-behavioral conjoint therapy was feasible and acceptable, and was associated with clinically meaningful reductions in PTSD symptoms and improvements in relationship satisfaction, suggesting promise for this treatment approach.

Abstract

Healing together: Results from a pilot trial of 3,4-Methylenedioxymethamphetamine-enhanced cognitive-behavioral conjoint therapy for posttraumatic stress disorder.

In the evidence

This study is part of the evidence base for 2 syntheses in the library. Here is how each one recorded it.

  • State of the evidence: MDMA for PTSD Supports

    MDMA-enhanced cognitive-behavioral conjoint therapy was feasible and acceptable and was associated with clinically meaningful PTSD symptom reductions and improved relationship satisfaction.

    Synthesized

  • State of the evidence: PTSD Supports

    MDMA-enhanced cognitive-behavioral conjoint therapy was feasible and acceptable and was associated with clinically meaningful PTSD symptom reductions and improved relationship satisfaction.

    Synthesized

Comparable studies

Other non-randomized and open-label trials on MDMA for PTSD, most cited first.

Study Year Design Participants
Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4-methylenedioxymethamphetamine-assisted psychotherapy: a prospective long-term follow-up study. Adults with chronic, treatment-resistant PTSD 2013 Long-term follow-up of a completed trial n = 19
MDMA-facilitated cognitive-behavioural conjoint therapy for posttraumatic stress disorder: an uncontrolled trial. Couples in which one partner was diagnosed with PTSD 2020 Pilot study n = 6
Culturally informed research design issues in a study for MDMA-assisted psychotherapy for posttraumatic stress disorder People of color with posttraumatic stress disorder 2019 Phase 2 open-label multisite study
3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for victims of sexual abuse with severe post-traumatic stress disorder: an open label pilot study in Brazil. Patients with PTSD secondary to sexual abuse 2021 Open-label clinical trial n = 3
Relational and Growth Outcomes Following Couples Therapy With MDMA for PTSD. Romantic dyads where one partner had PTSD 2021 Pilot trial n = 6

Citations in the library

Cites 10

and 5 more in the library

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MDMA PTSD

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