We take a wide view across the emerging research into psychedelics and psychosis/madness, to emphasize the need for not just more but also wise research at these intersections. We note the growing rate of publications on the use of psychedelics by people who have had experiences of psychosis/madness, and make our arguments around a narrative report of the lead author, who experienced a...
This paper presents qualitative data reported by individuals with histories of psychotic symptoms and experiences who engaged in naturalistic psychedelic use compiled as a case series. Through detailed first-person narratives, we explore how both classic and non-classic psychedelic experiences were subjectively experienced and integrated by individuals in this population, which is usually...
ULAKES JOURNAL OF MEDICINEMay 13, 2026Maria Eduarda Marquezi Machioni, Giulia Argueles de Oliveira, Ana Luísa da Silva Rueda et al.
Diante da crescente prevalência dos diagnósticos de transtornos ansiosos no Brasil e no mundo, o presente artigo visa analisar as contribuições das substâncias psicodélicas no tratamento dos transtornos. Por meio de uma revisão narrativa, foram examinados estudos sobre o potencial terapêutico de compostos como LSD, psilocibina, ayahuasca e MDMA. Os resultados colhidos apontam que essas...
Zusammenfassung Die Psychedelika-assistierte Therapie (PAT) hat sich in den letzten Jahren zu einem der dynamischsten Forschungsfelder der Psychiatrie entwickelt. Während die beste Evidenz bisher für depressive Störungen und posttraumatische Belastungsstörungen vorliegt, wird PAT zunehmend auch bei anderen nicht-psychotischen Störungen untersucht. Jenseits der Symptomlinderung rückt die...
Zusammenfassung Substanzkonsumstörungen (SUD) sind chronische Erkrankungen mit hohen Rückfallraten und begrenzter Wirksamkeit etablierter Behandlungen. Vor diesem Hintergrund rückt die psychedelisch-assistierte Psychotherapie (PAP) mit Psilocybin und LSD zunehmend in den Fokus; die Literatur berichtet Hinweise auf mögliche Effekte insbesondere bei AUD und affektiven Symptomen. Ziel der Studie:...
Background The use of psychedelics for clinical purposes and psychological healing is well-documented across many settings, often addressing trauma or mood disorders. Two gaps remain underexplored: (1) the use of psychedelics for psychological healing by gender-diverse individuals, and (2) the personal therapeutic use of psychedelics in non-clinical settings and how this shows up in...
Background: Treatment-resistant depression (TRD) affects a significant proportion of individuals with major depressive disorder and remains difficult to manage with conventional treatments. Psychedelic-assisted therapies and neuromodulation have emerged as innovative interventions targeting neurobiological mechanisms beyond traditional antidepressant approaches. Objectives: This scoping review...
Mindfulness-based interventions are efficacious nonpharmacologic treatments for chronic pain, yet the psychological mechanisms mediating the pain-relieving effects of mindfulness-based interventions remain incompletely understood. One potential mechanism may involve nondual awareness, a state of consciousness characterized by attenuation of the subject-object duality, reduced self-referential...
Research SquareMay 11, 2026Chloë K Walters, Sarentha Chetty, Thankhoe A Rants’o et al.
preprint
Abstract Background: Conventional pharmacotherapy for treatment-resistant depression (TRD) has been found to provide limited benefit in a subset of patients. Psilocybin‑assisted therapy has emerged as a promising modality due to its rapid‑acting antidepressant effects and favourable tolerability profile shown in early trials. Despite growing research interest in psilocybin‑assisted therapy the...
Interest in psychedelic-assisted therapy (PAT) is surging across research and medical communities, prompting the discussion of policy shifts that reflect growing openness to implementing psychedelics in clinical practice. State-level psychedelic reform in the United States has accelerated since 2019, with legalization projected to reach most states within the next decade if trends follow those...