Health, environment and sustainable development: interdisciplinary approach
April 30, 2025
Saara Susan Sevander, Marja-Liisa Susan Rissanen
The purpose of the study was to describe the benefits and harm of using psychedelics in the treatment of patients with mental health and substance abuse disorders. The study focused on classic psychedelics, specifically psilocybin and LSD. The study was carried out as an integrative literature review and the data was sought using Medic, Cinahl, PubMed MEDLINE and PsycINFO databases. A total of...
Klinická farmakologie a farmacie
April 29, 2025
Michal Židó, Tomáš Páleníček, Ivana Štětkářová
Psychedelika jsou psychoaktivn ltky, kter bezprostedn po uit typicky vyvolvaj zmny vnmn, mylen, emotivity a kognitivnch proces. V posledn dob se intenzivn zkoum jejich antidepresivn a anxiolytick efekt. Hlavn vhodou tchto ltek je rychl nstup inku s dlouhodobm inkem po podn jedn i jen nkolika mlo dvek. Maj tak dobr bezpenostn profil. Dal vyuit mohou mt tyto ltky v lb chronickch bolest u...
April 28, 2025
Charmaine Husum
This chapter explores the key differences between entheogens and synthetic psychedelics, focusing on their origins, cultural contexts, and effects on consciousness. Entheogens are naturally occurring substances, such as psilocybin, ayahuasca, and peyote, traditionally used by Indigenous cultures for spiritual and healing purposes. These substances are often consumed in ceremonial settings with...
Journal of Psychedelic Studies
April 25, 2025
Przemysław Rupiński, Weronika Drabek, Paweł Holas
2 citations
Abstract Background and Aims This systematic review examines the association between psychedelic use and enhanced life purpose and meaning, as assessed by the Meaning in Life Questionnaire (MLQ) and the Purpose in Life Scale (PILS). Interest in psychedelics' therapeutic potential has grown, with some studies suggesting that these substances encourage meaningful psychological insights that...
Revue Médicale Suisse
April 23, 2025
Louise Penzenstadler, Sandra Baudois, Alma Lingenberg et al.
Psychedelics, such as psilocybin and lysergic acid diethylamide, modulate neuroplasticity and brain connectivity via 5-HT2A receptors. Their efficacy has been demonstrated in depression and anxiety, where they are particularly interesting because of their rapid and long-lasting effect. They could also be beneficial for addictions, post-traumatic stress, and obsessive-compulsive disorder. This...
Pharmacological Reviews
April 23, 2025
Benjamin R. Cummins, Gerald Billac, David E Nichols et al.
62 citations
Serotonin 5-HT2A receptors were one of the first serotonin receptors to be pharmacologically characterized. In mammals, they are expressed throughout the body in nearly every cell and tissue type, with the highest density in cortical layer V of the brain. They are involved in several aspects of normal physiological processes and behaviors and have been implicated in the etiology of...
Journal of Psychedelic Studies
April 22, 2025
Sophie van der Helder, Krista J. Siefried, Liam Acheson et al.
1 citation
Improved outcomes for substance use disorders have been described following non-clinical (“naturalistic”) psychedelic use. This exploratory study aimed to describe the naturalistic psychedelic experiences of people with substance use concerns and their reported needs and perceived utility of psychosocial support following naturalistic psychedelic use to integrate experiences and achieve...
Psychoactives
April 22, 2025
Kerem Kemal Soylemez, Emma Marie de Boo, Joanne Lusher
7 citations
Psychedelic substances have recently emerged as a promising method for treating mental health conditions, despite a history of stigmatization and restriction in use. The present review synthesizes existing literature on the therapeutic potential of psychedelics such as LSD, psilocybin, and MDMA in addressing specific mental health conditions like depression, anxiety, and addiction. On reviewing...
Schizophrenia Bulletin
April 17, 2025
Nathan H. Heller, Frederick S. Barrett, Tobias Buchborn et al.
3 citations
Abstract Background and Hypothesis Visual hallucinations (VH) are a core symptom of both Lewy body diseases (LBDs; eg, Parkinson’s disease and dementia with Lewy bodies) and serotonergic psychedelics (SPs; eg, psilocybin and mescaline). While these conditions differ in etiology, overlapping phenomenology, and neural mechanisms suggest shared pathways. This review explores similarities and...
Biology direct
April 10, 2025
Matteo Ardini, Francesco Angelucci, Francesca Rea et al.
The "psychedelic renaissance" is sparking growing interest in clinical research, along with a rise in clinical trials. Substances such as 3,4-methylenedioxymethamphetamine (MDMA), psilocybin and N,N-dimethyltryptamine (DMT) are involved. The focus of this paper is on indolethylamine N-methyltransferase (INMT), a crucial enzyme in the biosynthesis of key compounds, including DMT, which meets...