Frontiers in Psychiatry
June 24, 2026
Kathryn Fletcher, Nadine Ezard, Krista J. Siefried et al.
Background Methamphetamine use disorder (MAUD) is associated with substantial psychiatric and physical morbidity, and current treatment options remain limited. Ketamine-assisted psychotherapy (KAP) has shown promise in substance use disorders, but little is known about how individuals experience and interpret this intervention, particularly in MAUD. Qualitative investigation may provide insight...
AJNR. American journal of neuroradiology
April 24, 2026
Joga Chaganti, Krista J. Siefried, Veda S Vyakaranam et al.
Methamphetamine (MA) use disorder is associated with widespread disruption of large-scale brain networks involved in cognitive control, attention, and salience processing. Resting-state functional MRI (rs-fMRI) provides a means to characterize these alterations; however, little is known about the capacity for functional network reorganization following targeted intervention. The purpose of this...
Addiction
December 22, 2025
Jonathan Brett, Toby Lea, Elizabeth Knock et al.
Abstract Background and aims There is an urgent unmet need for novel treatments for methamphetamine (MA) use disorder. We explored the qualitative experiences of people participating in a study of psilocybin‐assisted psychotherapy (PAT) to treat MA use disorder. Design and setting Qualitative study of participants enrolled in a single arm, open‐label pilot study of PAT for MA use disorder...
Journal of Psychedelic Studies
April 22, 2025
Sophie van der Helder, Krista J. Siefried, Liam Acheson et al.
1 citation
Improved outcomes for substance use disorders have been described following non-clinical (“naturalistic”) psychedelic use. This exploratory study aimed to describe the naturalistic psychedelic experiences of people with substance use concerns and their reported needs and perceived utility of psychosocial support following naturalistic psychedelic use to integrate experiences and achieve...
BMJ Open
February 10, 2025
Kathryn Fletcher, Nadine Ezard, Krista J. Siefried et al.
1 citation
Methamphetamine use disorder is a significant public health concern. No pharmacological treatment options currently exist for methamphetamine use disorder, and psychotherapy is only moderately effective. Preliminary evidence suggests that ketamine-assisted psychotherapy produces sustained improvements in substance use and mental health symptomatology. In addition to direct antidepressant...