Journal of Psychopharmacology
December 10, 2024
Mattia Marchi, Riccardo Farina, Karim Rachedi et al.
13 citations
Background: The interest in psychedelics as a therapeutic intervention for existential distress of people with terminal illness grounds on their mechanism of action and effect on the spiritual/existential aspects accompanying end-of-life experiences. Aims: This systematic review and network meta-analysis aimed at examining the efficacy and safety of psychedelic compounds for existential...
interconnections journal of posthumanism
December 9, 2024
Keith Williams, Michelle Braunstein
This interdisciplinary research paper recombines Indigenous knowledges, postcolonial and new materialist theory, as well as fictional vignettes and drawings, to critically examine the biological synthesis of psilocybin through yeast. Against the backdrop of the “psychedelic renaissance” and consensus in the synthetic biology industry that generally, edited genes are “beyond containment”, the...
Archives of Neuroscience
December 9, 2024
Nader Charkhgard, Amin Afshar, Nasim Nadi Moghadam et al.
: Human progress across various dimensions has led to changes in approaches aimed at achieving greater success. Throughout human history, people have utilized plants and medicines from their surroundings to enhance productivity. However, this use has evolved over time, and it is clear that the use of these resources will continue to increase in the future. These tools will not only improve...
International Journal of Psychology
December 6, 2024
Monica Schweickle, Ted Cassidy
Purpose: The goal of this case report is to illustrate the implementation of 3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy for posttraumatic stress disorder (PTSD) and learning points for health professionals in the translation of psychedelic assisted therapy research into clinical practice. We present our key learnings and 6-month follow up data from one of the first patients to...
Frontiers in Psychology
December 6, 2024
Sean Noah, Earth Erowid, Fire Erowid et al.
5 citations
Introduction Psychedelic compounds such as LSD, psilocybin, mescaline, and DMT can dramatically alter visual perception. However, the extent to which visual effects of psychedelics consistently vary for different substances is an open question. The visual effects of a given psychedelic compound can range widely both across and within individuals, so datasets with large numbers of participants...
The British Journal of Psychiatry
December 5, 2024
Emma S Høgsted, Vincent Beliveau, Brice Ozenne et al.
4 citations
Background Using [ 18 F]altanserin, a serotonin 2A receptor (5-HT 2A R) antagonist Positron Emission Tomography (PET) tracer, a positive association between cortical 5-HT 2A R binding and the inward-directed facets of neuroticism has been demonstrated in healthy individuals. Psilocybin, a 5-HT 2A R agonist, shows promise for the treatment of depression, reducing neuroticism and mood symptoms...
Translational Psychiatry
December 5, 2024
Bettina Habelt, Dzmitry Afanasenkau, Cindy Schwarz et al.
6 citations
Patients with alcohol use disorder (AUD) who seek treatment show highly variable outcomes. A precision medicine approach with biomarkers responsive to new treatments is warranted to overcome this limitation. Promising biomarkers relate to prefrontal control mechanisms that are severely disturbed in AUD. This results in reduced inhibitory control of compulsive behavior and, eventually, relapse....
Translational Psychiatry
December 4, 2024
Kenneth Shinozuka, Katarina Jerotic, Pedro A. M. Mediano et al.
17 citations
Serotonergic psychedelics induce altered states of consciousness and have shown potential for treating a variety of neuropsychiatric disorders, including depression and addiction. Yet their modes of action are not fully understood. Here, we provide a novel, synergistic understanding of psychedelics arising from systematic reviews and meta-analyses of three hierarchical levels of analysis: (1)...
Neuroscience Applied
December 2, 2024
Kate Godfrey, Brandon Weiss, Joseph Peill et al.
5 citations
This study investigated the effects of a single high-dose of psilocybin on personality traits in psychedelic-naïve healthy volunteers. These data originate from a larger within-subjects fixed-order design trial, where a single high dose of psilocybin (25 mg) was administered in a psychologically supportive setting and was compared against a (one-month) prior, 1 mg 'placebo' dose. Personality...
Alzheimer s & Dementia
December 1, 2024
Jitendra Kumar Sinha, Shampa Ghosh, Krishna Kumar Singh et al.
1 citation
Abstract Background Traditionally associated with recreational and spiritual uses, psychedelics have gained attention in psychotherapy for their therapeutic potential. Functioning as potent 5‐hydroxytryptamine (5HT) agonists, these compounds have demonstrated the ability to enhance neural plasticity by activating serotoninergic and glutamatergic systems. Despite these recognized effects, their...