The symbolic architecture of non-ordinary consciousness remains largely unmapped in cognitive science and artificial intelligence. While conventional models prioritize rational coherence, altered states such as those induced by psychedelics reveal distinct symbolic regimes characterized by recursive metaphor, ego dissolution, and semantic destabilization. We present \textit{Glyph}, a generative...
Abstract. Galay KV, Plimaco SMY. 2025. Mycochemical screening, antioxidant, and cytotoxic properties of Panaeolus cyanescens. Nusantara Bioscience 17: 137-154. This study focuses on exploring the subtleties of the hallucinogenic mushroom Panaeolus cyanescens Sacc., known for its psychoactive component psilocybin. The study focuses on exploring the phytochemical, antioxidant, and cytotoxic...
This retrospective case study features a woman in her mid-50s who spent her childhood in a religious community plagued by sexual abuse of children. She was abused by her father for more than a decade. The church and her mother ignored her reports about it. In her early twenties, she enrolled herself in the Erhard Seminars Training program that destabilized her, inducing a first-onset psychosis,...
Mood disorders and existential distress impact those with cancer or a serious illness at higher rates than the general population. There have been limited pharmacological advances in recent years, and available psychological interventions vary in degree of impact and durability as a treatment modality in this population. A recent renaissance in psychedelic research has suggested that this class...
The intensity of the psychedelic experience has been hypothesized as the main predictor of response to a psychedelic treatment. This study aimed to investigate factors that may be associated with the intensity of mystical experiences during naturalistic psychedelic use. The data of this comprehensive sample were aggregated from four previous retrospective surveys, where mystical experience...
In recent years, there has been a significant surge of interest in psychedelic research. These studies encompass both neuroscience and their potential clinical applications. This phenomenon, often referred to as the "Psychedelic Renaissance", includes studies on compounds such as psilocybin, MDMA, DMT, and LSD used for the treatment of depression, post-traumatic stress disorder, anxiety, and...
Psychedelic substances such as psilocybin have recently gained attention for their potential therapeutic benefits in treating depression and other mental health problems. However, individuals with bipolar disorder (BD) have been excluded from most clinical trials due to concerns about manic switches or psychosis. This study aimed to systematically examine the effects of recreational psychedelic...
Psychedelic science is growing at a rapid pace, and as evidence accrues, we will most likely see authorization of the use of substances such as psilocybin and MDMA augmenting the effects of psychotherapy in the coming years. Lykos therapeutics (previously called MAPS PBC) recently filed a New Drug Application to the FDA in the US and expects to be able to offer MDMA as a prescribable drug in...
IGI Global eBooksMarch 13, 2025K.Suresh Kumar, Sandeep Kumar Davuluri, Lakshman Kumar Kanulla et al.2 citations
Historical stories and contemporary clinical studies have shown substantial promise for the therapeutic use of psychedelics for the treatment of mood disorders such as depression. Comp360 is COMPASS Pathways' unique synthetic formulation of psilocybin. A recent randomised double-blind phase-II b research showed that it was safe and effective for those with treatment-resistant depression. The...
Biological PsychiatryMarch 8, 2025Jonathan Repple, Maximilian Bayas, Chiara Möser et al.8 citations
After decades of limited progress in depression treatment, recent advancements have sparked renewed interest in developing novel antidepressants, particularly rapid-acting antidepressants (RAADs). Despite these promising developments, there remains a significant gap in research on bipolar depression. While several antipsychotics have been investigated for their efficacy in bipolar depression...