In this chapter, we consider the therapeutic potential of psychedelics, such as psilocybin and midomafetamine (MDMA), as a novel response to deepening mental health crises. In particular, we examine this in the context of restrictive drug control systems across Europe (including the United Kingdom). Whilst promising results from several clinical studies have fed into and helped to perpetuate a...
Responders were distinguished by narratives of inner dialogue and adaptive coping, while non-responders emphasized sensory and affective descriptions and suppressive coping. Inner dialogue may constitute a distinct therapeutic mechanism, highlighting the importance of preparation and integration in psilocybin-assisted psychotherapy.
Falcon, J. 2025. “Anthropology of Psychedelics.” Anthropology of Consciousness 36: e70002, 1-14 https://doi.org/10.1111/anoc.70002. In Paragraph 1 of the “Psilocybin” section, the sentence “Although it is difficult to find archaeological evidence of their use in prehistory, some estimate their use may date as far back as 40 000 years based on cave paintings found in Algeria (Froese et al....
CNS DrugsJanuary 17, 2026Gaëlle Rached, Anna Campana, Dimitri Fiani et al.1 citation
Monoamine oxidase inhibitors (MAOIs) remain an important option for patients with treatment-resistant depression (TRD) and other psychiatric conditions, despite potentially serious drug-drug interactions and associated dietary tyramine restrictions. However, they are rarely prescribed in patients with comorbid substance use disorders (SUDs) due to concerns about potential drug interactions and...
Classical psychedelics have regained interest for their potential to treat psychiatric and neurological disorders, and explore neural mechanisms supporting perception, cognition, and mood. Acute psychedelic effects have been linked to increases in brain complexity and entropy, but it is unclear if these changes are specific to psychedelics or reflect more general psychoactive effects. Here, we...
Os transtornos depressivos representam uma das principais causas de incapacidade global, afetando de forma significativa o funcionamento emocional, social e ocupacional dos indivíduos. Apesar da ampla disponibilidade de antidepressivos convencionais, muitos pacientes apresentam resposta insuficiente ou efeitos adversos limitantes, especialmente aqueles com depressão resistente ao tratamento...
Recent psychedelic patent activity highlights a strategic shift from experiential framing toward chemically and pharmacokinetically precise neurotherapeutics. Four recent patent applications collectively span solid-state control of psilocybin, exposure-shaped intramuscular and infusion-based dosing, and chemically diversified monoaminergic scaffolds with defined transporter and receptor...
Abstract Aims: The investigation of psychedelics as potential therapies has expanded dramatically in the past decade, leading to their study in a wide range of conditions. Here, we characterize all ongoing clinical trials utilizing a psychedelic intervention with the goals of identifying trends in experimental design and application and discuss how findings from individual, ongoing clinical...
High Resolution Image Download MS PowerPoint Slide Novel psychoactive substances (NPS) remain an ongoing challenge for public health, forensic laboratories, and regulatory agencies, especially when they are chemically related to controlled tryptamines but are marketed as legal alternatives. In the United States, the Federal Analogue Act (FAA) was intended to restrict such substances; however,...
Psychedelics are a diverse class of psychoactive compounds that profoundly alter perception, cognition, and emotional states. Recently, classical serotonergic agents, such as psilocybin and lysergic acid diethylamide (LSD), along with atypical agents such as methylenedioxymethamphetamine (MDMA, ecstasy) and ibogaine, have attracted renewed attention due to their rapid and sustained clinical...