European Psychiatry
June 1, 2022
L. Silva, L. Bravo
Introduction Ayahuasca is an hallucinogenic tea prepared from the Amazonian vine Banisteriopsis caapi and the leaves of the plant Psychotria Viridis. Banisteriopsis caapi contains monoamine oxidase inhibitors (MAO) that render the N, N-dimethyltryptamine (DMT) of Psychotria Viridis active. This brew is being used as a sacrament in syncretic religions in urban areas of Brazil and worldwide with...
European Psychiatry
June 1, 2022
Johannes T. Reckweg, Natasha L. Mason, Cees van Leeuwen et al.
3 citations
Introduction 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) is a tryptamine with ultra-rapid onset and short duration of psychedelic effects. Prospective studies for other tryptamines have suggested beneficial effects on mental health outcomes. Objectives In preparation for a study in patients with depression, the present study GH001-HV-101 aimed to assess the impact of four different dose levels...
European Psychiatry
June 1, 2022
Pierre Chue, A. Andreiev, E. Bucuci et al.
6 citations
Introduction The 5-HT 2A agonist classic psychedelic, psilocybin (O-phosphoryl-4-hydroxy-N,N-dimethyltryptamine) is a tryptophan, indole-based alkaloid present in up to 2% of certain hallucinogenic “magic” mushroom species; typically Psilocybe azurescens, semilanceata, and cyanescens,. In addition, mushrooms may contain psilocin (4-hydroxy-N,N-dimethyltryptamine). Both are indolylalkylamines...
Advances in Clinical Medical Research and Healthcare Delivery
May 31, 2022
Neil Harjai
1 citation
We are amidst a 'Renaissance' in the field of psychedelic psychiatry. For several decades, following a period of promising research, governmental barriers and regulations halted any research into the utility of these substances in psychiatry. Over the past few decades, however, we are seeing a revival of these studies due to an abundance of positive findings as well as the need for improved...
Journal of Psychopharmacology
May 30, 2022
Chaitra Jairaj, James J Rucker
13 citations
Background: Postpartum depression (PPD) is a major public health concern and has, at its core, a sense of maternal ‘disconnection’ – from the self, the infant, and the support system. While PPD bears similarities with MDD, there is increasing evidence for its distinct nature, especially with the unique aspect of the mother-infant relationship. Current treatment modalities for PPD, largely based...
Cureus
May 23, 2022
Kawther N Elsouri, Sahand Kalhori, Diego Colunge et al.
15 citations
Post-traumatic stress disorder (PTSD) is an anxiety disorder that often presents after exposure to a traumatic, life-threatening event. Experiencing a traumatic event is not rare, with inciting incidents ranging from being burglarized to politically motivated genocide. While traditional psychopharmacology and psychotherapy are the mainstays of the treatment of PTSD currently, psychoactive drugs...
Pharmaceuticals
May 23, 2022
Danish Mahmood, Sattam Khulaif Alenezi, Md Jamir Anwar et al.
29 citations
Psychedelics such as lysergic acid diethylamide (LSD), psilocybin (magic mushrooms), and mescaline exhibit intense effects on the human brain and behaviour. In recent years, there has been a surge in studies investigating these drugs because clinical studies have shown that these once banned drugs are well tolerated and efficacious in medically supervised low doses called microdosing....
Frontiers in Forests and Global Change
May 23, 2022
Dominique Strauss, Soumya Ghosh, Zurika Murray et al.
30 citations
Psilocybin and psilocin, two psychoactive components found in “magic mushrooms,” have therapeutic potential in a number of mental health disorders without the addictiveness and overdose risks found in other mind-altering drugs, such as cocaine, methamphetamines and alcohol. Psychedelic mushrooms occur naturally, are wide distributed and easily accessible. The need for reviews and comprehensive...
Frontiers in Psychology
May 23, 2022
David B. Yaden, Dylan Earp, Marianna Graziosi et al.
106 citations
The acute subjective effects of psychedelics are responsive to users’ expectations and surroundings (i.e., “set and setting”). Accordingly, a great deal of thought has gone into designing the psychosocial context of psychedelic administration in clinical settings. But what theoretical paradigms inform these considerations about set and setting? Here, we describe several historical, sociological...
Zenodo (CERN European Organization for Nuclear Research)
May 13, 2022
Liliana Irizabal
preprint
This project is a systematic review that highlights how beneficial psychedelic psychotherapy can be to those suffering with mental illness. The three mental illnesses chosen to be analyzed in the literature were depression, post-traumatic stress disorder (PTSD), and anxiety. The drugs used in the specific articles included Psilocybin, Ayahuasca(DMT), and MDMA (3,4-methylenedioxymethamphetamine;...