Biomedicine & Pharmacotherapy
December 31, 2023
David Fabregat-Safont, Alex Gomez-Gomez, Francisco Madrid-Gambin et al.
Psychedelics are classical hallucinogen drugs that induce a marked altered state of consciousness. In recent years, there has been renewed attention to the possible use of classical psychedelics for the treatment of certain mental health disorders. However, further investigation to better understand their biological effects in humans, their mechanism of action, and their metabolism in humans is...
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
December 31, 2023
Francisco Madrid-Gambin, David Fabregat-Safont, Alex Gomez-Gomez et al.
12 citations
Psychedelics are classical hallucinogen drugs that induce a marked altered state of consciousness. In recent years, there has been renewed attention to the possible use of classical psychedelics for the treatment of certain mental health disorders. However, further investigation to better understand their biological effects in humans, their mechanism of action, and their metabolism in humans is...
December 26, 2023
Burton J. Tabaac, Kenneth Shinozuka, Alejandro Arenas et al.
preprint
Background: Psychedelic drugs have recently emerged as plausibly effective pharmacological agents for the management of depression, anxiety, and other neuropsychiatric conditions, including conditions that have not benefited from prior interventions. The latter half of the twentieth century marked a revolution in the treatment of depression, anxiety, and psychosis, exemplified by the...
Research, Society and Development
December 13, 2023
Caíque Gois Cardoso, Milena de Barros Viana
2 citations
Introduction: With the progressive advancement of clinical and experimental trials aimed at investigating the pharmacotherapeutic potential of psychedelic substances, there is also the development of other conceptions of use, not only for the treatment of psychiatric disorders, but also for the improvement of emotional/cognitive functions. Objective: The present study is a systematic review of...
Frontiers in Psychiatry
December 6, 2023
Elliot Marseille, Manish Agrawal, Paul Thambi et al.
40 citations
Objective To compare group and individual psychedelic-assisted therapy in terms of clinician time, costs and patient access. Methods Using 2023 data from two group therapy trial sites, one using 3,4-Methylenedioxymethamphetamine (MDMA) to treat posttraumatic stress disorder (PTSD), and one using psilocybin to treat major depressive disorder (MDD), we compared overall variable costs, clinician...
Molecules
December 5, 2023
Marjolein Doesburg-Van Kleffens, Amy Marisa Zimmermann-Klemd, Carsten Gründemann
13 citations
Peyote (Lophophora williamsii) is a cactus that contains various biologically active alkaloids—such as pellotine, anhalonidine, hordenine and mescaline. Here, mescaline induces the psychoactive effects of peyote through the activation of the serotonin 5-HT2A receptor and the subsequent release of calcium (Ca2+) from the endoplasmic reticulum (ER). Moreover, an evaluation of the therapeutic...
Journal of Military, Veteran and Family Health
December 1, 2023
Zachary Skiles, James R Dixon, Dan Friedrich et al.
The field of psychedelic-assisted psychotherapy and state-run psychedelic services will need to adequately train and certify facilitators to meet the anticipated demand for access. This article explores the role of peer support in the setting of medical and non-medical supervised psychedelic administration. Existing peer-support frameworks from both the psychedelic and the Veteran communities...
Journal of Military, Veteran and Family Health
December 1, 2023
Erika Dyck, Gregory P. Marchildon
LAY SUMMARY The historical relationship between psychedelic drugs and the military has often been characterized in terms of drug misuse or the connection between drugs like d-lysergic acid diethylamide (LSD) or psilocybin (magic mushrooms) contributing to anti-war sentiments. Recent clinical evidence, however, suggests these cultural associations may be overshadowing the potential for...
Journal of Military, Veteran and Family Health
December 1, 2023
Emmanuelle A. D. Schindler, Jason J. Sico
LAY SUMMARY Patients with headache disorders, such as migraine or cluster headache, often have poor quality of life and can be disabled by their condition. Military members and Veterans have a high risk of developing a headache disorder, particularly because they are also at risk for brain injury through head trauma. New headache treatments are needed, because the available treatments may not...
Neuroimage
December 1, 2023
Stefano Delli Pizzi, Piero Chiacchiaretta, Carlo Sestieri et al.
27 citations
The role of the thalamus in mediating the effects of lysergic acid diethylamide (LSD) was recently proposed in a model of communication and corroborated by imaging studies. However, a detailed analysis of LSD effects on nuclei-resolved thalamocortical connectivity is still missing. Here, in a group of healthy volunteers, we evaluated whether LSD intake alters the thalamocortical coupling in a...