Psilocybin: all studies (page 202) - The Consciousness Library

Efficacy and Safety of Psychedelics in Mental Disorder Cases: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials

Journal of Clinical Medicine December 29, 2025 Monika Dominiak, Adam Gędek, Szymon Modrzejewski et al. 2 citations

Background: Psychedelic-assisted therapy is gaining renewed attention as a potential treatment for various mental disorders. Despite increasing numbers of randomized controlled trials (RCTs) and meta-analyses, a comprehensive synthesis of the evidence across different substances and indications is lacking. This umbrella review aims to evaluate the effectiveness and safety of...

DOI: 10.3390/jcm15010253 MDMA Psilocybin Major depressive disorder Alcohol use disorder +8

Adverse events associated with classic psychedelics and MDMA: a real-world population-based study using the WHO pharmacovigilance database (VigiBase)

Psychiatry Research December 29, 2025 Omer A. Syed, Sean M. Nestor, Muhammad Ishrat Husain et al. 1 citation

Psychedelic use has greatly increased within clinical and recreational settings over recent years. While demonstrating a favorable safety profile within certain clinical populations, little empirical research has explored safety of psychedelic use within real-world samples. Using the World Health Organization (WHO) VigiBase, a comprehensive global pharmacovigilance database with voluntary...

DOI: 10.1016/j.psychres.2025.116929 Psilocybin MDMA Mescaline Ecstasy +13

A Systematic Review of the efficacy, safety, and Tolerability of Psychedelics in the Treatment of post-traumatic Stress Disorder

Current Treatment Options in Psychiatry December 26, 2025 Manasicha P. Wongpaiboon, Jackson L. Shelton, Eric Delgado Rendon et al.

Purpose A systematic review was conducted to synthesize the efficacy, safety, and tolerability of psychedelics including ketamine, MDMA, ayahuasca, LSD, DMT, ibogaine, and psilocybin in the treatment of PTSD. Recent Findings Among 5,155 studies identified, 42 studies met criteria and were included in our systematic review. Ketamine consistently produced rapid symptom improvement that attenuated...

DOI: 10.1007/s40501-025-00373-w Full text Ketamine Psilocybin Hallucinogens 3,4-methylenedioxymethamphetamine +1

The 3D-ASCr scale: A revalidation of the core dimensions of the Altered States of Consciousness Rating Scale 5D(11)-ASC for psychedelic research.

Journal of Psychopharmacology December 26, 2025 Kurt Stocker, Matthias Hartmann, Yasmin Schmid et al. 5 citations

The Altered States of Consciousness Scale (3/5D-ASC or 11-ASC) is widely used to assess non-ordinary states of consciousness, particularly for psychedelic research. However, its original dimensional model (3D-ASC within 5D-ASC) and later 11-subscale structure (11-ASC) have a hierarchically incompatible higher/lower-order structure. Although the 11-ASC offers superior model fit, the 3D-ASC...

DOI: 10.1177/02698811251397328 Full text DMT LSD Mescaline Psilocybin +1

Knowledge, perceptions, and use of psychedelics for mental health among autistic adults: An online survey

PLOS mental health December 26, 2025 Sahba Afsharnia, Vivian Liang, Yona Lunsky et al. 1 citation

Psychedelics such as psilocybin, LSD, and MDMA have shown promise in treating mental health conditions (e.g., depression, post-traumatic stress disorder) among neurotypical individuals, i.e., typically developing individuals without a diagnosed neurodevelopmental condition. However, their therapeutic potential for treating co-occurring mental-health conditions in autistic individuals remains...

DOI: 10.1371/journal.pmen.0000514 Psilocybin Anxiety Neurotypical Autism +5

The genus Psilocybe in Italy

Italian Botanist December 22, 2025 Giuseppe Venturella, Manuela Rollini, Giulia Mirabile et al.

In the absence of specific studies on the Psilocybe genus in Italy, we provide information on the taxonomy, habitat, ecology, and distribution of the nine taxa currently recorded for Italy. A nomenclatural update of Psilocybe taxa reported in the Checklist of Italian Fungi (Basidiomycetes), published in 2005, is provided and seven scientific binomials are confirmed. In addition, P. medullosa...

DOI: 10.3897/italianbotanist.20.181001 Psilocybin Checklist Genus Taxonomy biology +4

Allowing Similarities: Using Aldous Huxley’s Views on Mystical Experience to Assess the Import of Profound Unitive Experiences Occasioned by Psychedelic Substances

Religions December 22, 2025 Dana W. Sawyer

For more than four decades, the emphasis in the academic study of world religions has been on differences over similarities, and comparative analyses allowing for commonalities have become increasingly rare. This article argues that similarities nonetheless exist and should be studied. After disclaiming the judgment of other scholars that Aldous Huxley attempted to describe the “core” or...

DOI: 10.3390/rel17010009 Mysticism Psilocybin Experiential learning Telepathy +8

The CAnadian Network for Psychedelic-Assisted Cancer Therapy (CAN-PACT): A Multi-Phase Program Overview.

Current Oncology December 22, 2025 Linda E. Carlson, Harriet Richardson, Ron Shore et al. 1 citation

The CAnadian Network for Psychedelic-Assisted Cancer Therapy (CAN-PACT) was launched in 2025 to address urgent gaps in supportive care for Canadians with cancer experiencing demoralization syndrome (loss of meaning, dysphoria, disheartenment, helplessness, a sense of failure) and related psychosocial distress. CAN-PACT has six major objectives: (1) to develop a national interdisciplinary...

DOI: 10.3390/curroncol33010007 Full text Mindfulness Psilocybin Cancer Clinical trials +3

Psilocibina en cuidados paliativos: revisión sistemática de los efectos a nivel emocional y espiritual-existenciales

Revista Metropolitana de Ciencias Aplicadas December 21, 2025 Graciela Estefanía Toalombo-Eugenio, Katheryne Viviana Carrillo-Zavala, Verónica Giovanna Mayorga-Núñez

Anxiety, depression, and existential distress are common symptoms in palliative care and significantly impair patients’ quality of life. Psilocybin-assisted therapy, based on preparation, therapeutic support, and psychotherapeutic integration, has emerged as a promising intervention to alleviate this complex cluster of suffering. The aim of this systematic review was to synthesize the evidence...

DOI: 10.62452/hx8sfs74 Anxiety Psilocybin Coping psychology Palliative care +9

Subjective Effects of Psychedelics Are the Plausible Mechanism of Psychedelic Moral Enhancement Rather than a Risk. Comment on Tang, B.L. Psychedelics for Moral Bioenhancement in Healthy Individuals—A Violation of the Non-Maleficence Principle? Psychoactives 2025, 4, 5

Psychoactives December 17, 2025 Juuso Kähönen 2 citations

In a recent Psychoactives article, Bor Luen Tang argues against psychedelic moral bioenhancement (PMBE)—the use of classic psychedelics such as psilocybin to foster moral growth in healthy individuals [...]

DOI: 10.3390/psychoactives4040043 Psilocybin Mechanism biology Consciousness Moral disengagement +3