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Psilocybin: all studies

Page 103 of 440: studies 1,021 to 1,030 of 4,392, newest first. Back to the psilocybin overview

Research

A Plea for Nuance: Should People with a Family History of Bipolar Disorder Be Excluded from Clinical Trials of Psilocybin Therapy?

Psychedelic Medicine February 28, 2024 Joshua Woolley, Amanda E. Downey, Ellen Bradley et al. 2 citations

Balancing the need for effective treatments against the potential for serious adverse events in those undergoing psilocybin therapy with a family history of BD, we argue for caution in psychedelic clinical trials but not outright exclusion of these individuals. Our risk stratification tool allows for more nuanced inclusion and exclusion criteria.

Impact of Psilocybin on Peripheral Cytokine Production

Psychedelic Medicine February 28, 2024 Dana D. DiRenzo, Jamie Perin, Erika Darrah et al. 4 citations

This preliminary study suggests that a transient increase in cytokine production ≤1-week postpsilocybin may be found, although not consistently across patient populations. More broadly, peripheral cytokine production is possibly altered by psilocybin administration. ClinicalTrials.gov Identifier: NCT01988311.

Predicting the outcome of psilocybin treatment for depression from baseline fMRI functional connectivity.

Journal of Affective Disorders February 27, 2024 Debora Copa, David Erritzøe, Bruna Giribaldi et al. 31 citations

BackgroundPsilocybin is a serotonergic psychedelic drug under assessment as a potential therapy for treatment-resistant and major depression. Heterogeneous treatment responses raise interest in predicting the outcome from baseline data.MethodsA machine learning pipeline was implemented to investigate baseline resting-state functional connectivity measured with functional magnetic resonance...

Deciphering psilocybin: Cytotoxicity, anti-inflammatory effects, and mechanistic insights

International Immunopharmacology February 23, 2024 Salma Laabi, Claire LeMmon, Callie Vogel et al. 16 citations

A decade of clinical research has indicated psilocybin's effectiveness in treating various neuropsychiatric disorders, such as depression and substance abuse. The correlation between increased pro-inflammatory cytokines and the severity of neuropsychiatric symptoms, along with the known anti-inflammatory potential of some psychedelics, suggests an immunomodulatory role for psilocybin. This...

The effect of psilocybin on empathy and prosocial behavior: a proposed mechanism for enduring antidepressant effects.

npj Mental Health Research February 20, 2024 Kush V. Bhatt, Cory R. Weissman 29 citations

Psilocybin is a serotonergic psychedelic shown to have enduring antidepressant effects. Currently, the mechanism for its enduring effects is not well understood. Empathy and prosocial behavior may be important for understanding the therapeutic benefit of psilocybin. In this article we review the effect of psilocybin on empathy and prosocial behavior. Moreover, we propose that psilocybin may...

DOI: 10.1038/s44184-023-00053-8 (opens in new tab) Full text (opens in new tab) Psychedelics Mental health Depression treatment Social cognition

Indigenous psilocybin mushroom practices: An annotated bibliography

Journal of Psychedelic Studies February 19, 2024 Nicholas Spiers, Beatriz Caiuby Labate, Anna O. Ermakova et al. 27 citations

Abstract This annotated bibliography comprises 49 texts concerning psilocybin mushroom practices developed by Indigenous peoples. The books and articles have been selected for their academic rigor, relevance, and historical significance, and to foreground overlooked research and subject matter. This includes research on a plurality of contemporary practices and evidence of historical uses, from...

DOI: 10.1556/2054.2023.00297 (opens in new tab) Full text (opens in new tab) Psilocybin Indigenous Contextualization Annotated bibliography +6

NIDA: Psilocybin mushroom seizures rose significantly

Alcoholism & Drug Abuse Weekly February 16, 2024 Alison Knopf

A National Institute on Drug Abuse (NIDA)‐funded study published in the journal Drug and Alcohol Dependence titled “National and Regional Trends in Seizures of Shrooms (Psilocybin) in the United States, 2017‐2022” reported a significant increase in law enforcement seizures of psilocybin mushrooms, also known as “magic mushrooms” or “shrooms,” in the United States from January 2017 to December...

Effect of a single psilocybin treatment on Fos protein expression in male rat brain.

Neuroscience February 16, 2024 Douglas Funk, Joseph Araujo, Malik Slassi et al. 11 citations

Psilocybin has received attention as a treatment for depression, stress disorders and drug and alcohol addiction. To help determine the mechanisms underlying its therapeutic effects, here we examined acute effects of a range of behaviourally relevant psilocybin doses (0.1-3 mg/kg SC) on regional expression of Fos, the protein product of the immediate early gene, c-fos in brain areas involved in...

Corrigendum: Safety, feasibility, tolerability, and clinical effects of repeated psilocybin dosing combined with non-directive support in the treatment of obsessive-compulsive disorder: protocol for a randomized, waitlist-controlled trial with blinded ratings

Frontiers in Psychiatry February 16, 2024 Terence H. W. Ching, Lucia Amoroso, Calvin Bohner et al. correction

[This corrects the article DOI: 10.3389/fpsyt.2023.1278823.].