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Debora Copa

5 papers in the library · 36 citations · publishing 2024-2026

Papers

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Multimodal autonomic arousal tracks dose-dependent affective dynamics during the acute effects of DMT

bioRxiv May 4, 2026 Tomás Ariel D’amelio, Tomás Gil Garbagnoli, Jerónimo Rodríguez Cuello et al.

ABSTRACT Serotonergic psychedelics induce altered states of consciousness characterised by profound changes in emotional experience. Although psychedelics modulate autonomic arousal, sympathetic engagement during their affective effects remains poorly characterised. We recorded cardiac, electrodermal, and respiratory activity in 19 participants following inhalation of 20 or 40 mg of freebase...

Time-resolved Neural and Experience Dynamics of Medium- and High-dose N,N-Dimethyltryptamine (DMT).

Apollo (University of Cambridge) January 16, 2026 Evan Lewis-Healey, Carla Pallavicini, Federico Cavanna et al.

N,N-dimethyltryptamine (DMT) is a fast-acting psychedelic drug that induces a radical reorganization of conscious contents and brain dynamics. However, our understanding of how brain dynamics support psychedelic-induced conscious states remains unclear. We therefore present a repeated-measures dose-dependent study of the subjective and neural dynamics induced through DMT under naturalistic...

Time-resolved Neural and Experience Dynamics of Medium- and High-dose N,N-Dimethyltryptamine

Journal of Cognitive Neuroscience December 30, 2025 Evan Lewis-Healey, Carla Pallavicini, Federico Cavanna et al. 4 citations

N,N-dimethyltryptamine (DMT) is a fast-acting psychedelic drug that induces a radical reorganization of conscious contents and brain dynamics. However, our understanding of how brain dynamics support psychedelic-induced conscious states remains unclear. We therefore present a repeated-measures dose-dependent study of the subjective and neural dynamics induced through DMT under naturalistic...

Time-resolved neural and experience dynamics of medium- and high-dose DMT

bioRxiv Preprint Server December 19, 2024 Evan Lewis-Healey, Carla Pallavicini, Federico Cavanna et al. 1 citation preprint

N,N-Dimethyltryptamine (DMT) is a fast-acting psychedelic drug that induces a radical reorganisation of conscious contents and brain dynamics. However, our understanding of how brain dynamics support psychedelic-induced conscious states remains unclear. We therefore present a repeated-measures dose-dependent study of the subjective and neural dynamics induced through DMT under naturalistic...

Predicting the outcome of psilocybin treatment for depression from baseline fMRI functional connectivity.

J Affect Disord February 27, 2024 Debora Copa, David Erritzøe, Bruna Giribaldi et al. 31 citations

BackgroundPsilocybin is a serotonergic psychedelic drug under assessment as a potential therapy for treatment-resistant and major depression. Heterogeneous treatment responses raise interest in predicting the outcome from baseline data.MethodsA machine learning pipeline was implemented to investigate baseline resting-state functional connectivity measured with functional magnetic resonance...