Depersonalization disorder (DPD) is a debilitating dissociative condition with no proven treatments. Although the pathophysiology of DPD is poorly understood, there are reports of increased excitability of the prefrontal cortex in patients with this condition. The temporo-parietal junction may also play a major role in the conscious experience of the spatial unity of the normal self and body....
Evidence for the hypothesis that input to the apical tufts of neocortical pyramidal cells plays a central role in cognition by amplifying their responses to feedforward input is reviewed. Apical tufts are electrically remote from the soma, and their inputs come from diverse sources including direct feedback from higher cortical regions, indirect feedback via the thalamus, and long-range lateral...
As we are cognizant of only a fraction of the available visual inputs at any given time, how is information selected for access to consciousness? In particular, does the personal significance of stimuli influence perceptual selection? Given that self-relevant information is prioritized during various stages of processing, here we hypothesized that self-association may privilege access to...
This study compared subjective experiences and EEG patterns in 37 subjects when listening to live Vedic recitation and when practicing Transcendental Meditation (TM). Content analysis of experiences when listening to Vedic recitation yielded three higher-order code. Experiences during Vedic recitation were: (1) deeper than during TM practice; (2) experienced as an inner process; and (3)...
LSD (lysergic acid diethylamide) is a model psychedelic drug used to study mechanism underlying the effects induced by hallucinogens. However, despite advanced knowledge about molecular mechanism responsible for the effects induced by LSD and other related substances acting at serotonergic 5-HT2a receptors, we still do not understand how these drugs trigger specific sensory experiences....
Summary Altered self-experiences arise in certain psychiatric conditions, and may be induced by psychoactive drugs and spiritual/religious practices. Recently, a neuroscience of self-experience has begun to crystallise, drawing upon findings from functional neuroimaging and altered states of consciousness occasioned by psychedelic drugs. This advance may be of great importance for psychiatry.
Functional MRI (fMRI) studies have demonstrated that the rodent brain shows a default mode network (DMN) activity similar to that in humans, offering a potential preclinical model both for physiological and pathophysiological studies. However, the neuronal mechanism underlying rodent DMN remains poorly understood. Here, we used electrophysiological data to analyze the power spectrum and...
The use of mind–body therapies reaches back through history in the form of meditation and other spiritual practices focused on health and healing. In the modern medical setting, mind–body therapies are used to harness the connections between emotions and physiology to benefit health with a secular philosophy and intent. Common mind–body therapies include breath work, biofeedback, guided...
Abstract: This article explores the contribution of ethnographic studies to our understanding of multinational corporations, through a literature review and through a case study of BMW Plant Oxford. The study considers that ethnographic studies can provide a more complex view of power relations between managers and workers, and can develop embedded perspectives taking into account the...
How and which aspects of neural activity give rise to subjective perceptual experience-i.e. conscious perception-is a fundamental question of neuroscience. To date, the vast majority of work concerning this question has come from vision, raising the issue of generalizability of prominent resulting theories. However, recent work has begun to shed light on the neural processes subserving...