N,N-Dimethyltryptamine (DMT) is a classic psychedelic capable of inducing short-lasting but profound changes in consciousness. As with other psychedelics, the experience induced by DMT strongly depends upon contextual factors, yet the neurobiological determinants of this variability remain unknown. The present study investigated changes in neural oscillations elicited by inhaled DMT, and...
RATIONALE: Classic psychedelics are currently being studied as novel treatments for a range of psychiatric disorders. However, research on how psychedelics interact with other psychoactive substances remains scarce. OBJECTIVES: The current study aimed to explore the subjective effects of psychedelics when used alongside cannabis. METHODS: Participants (n = 321) completed a set of online surveys...
Figure: EP life, spirituality, scienceFigureA younger colleague and friend texted me after a young mother, eight months pregnant, was brought in with a life-ending, massive head injury from an MVC (a man fleeing police ran into her car). My colleague called OB and the NICU to come down for a crash C-section at the door to try to save the baby. When EMS rolled through the doors, the OB resident,...
Consciousness is supported by rich neuronal dynamics to orchestrate behaviors and conscious processing can be disrupted by general anesthetics. Previous studies suggested that dynamic reconfiguration of large-scale functional network is critical for learning and higher-order cognitive function. During altered states of consciousness, how brain functional networks are dynamically changed and...
Abstract A central question in neuroscience concerns the relationship between consciousness and its physical substrate. Here, we argue that a richer characterization of consciousness can be obtained by viewing it as constituted of distinct information-theoretic elements. In other words, we propose a shift from quantification of consciousness—viewed as integrated information—to its...
This paper considers three classes of analyses of the nature of consciousness: abstract theories of the functional organization of consciousness, and concrete proposals as to the neural substrate of consciousness, while providing a rationale for contesting non-neural and transcendental conceptualizations of consciousness. It indicates that abstract theories of the dynamic core of consciousness...
The unity of consciousness, or, more precisely, phenomenal unity, is an important property of consciousness and an important area of research in mathematical consciousness science and the scientific study of consciousness. Due to the numerous aspects and complexity of consciousness, the property tends to engender loose or inadequate characterizations. In this article, we introduce the concept...
I have a folder called "Inquiry" where I have put all the material I have gathered on this project.Basically, this is an inquiry on inquiry.The Greeks, of course, figure in it -including the pre-Socratics, such as Heraclitus -and in modern times -Heidegger: for example with his articulation of the disclosure of Being, his idea of the Lichtung, or clearing, into which Being reveals itself, and...
Reality shifting (RS) is a trendy mental activity that emerged abruptly following the flare-up of the COVID-19 pandemic in 2020 and seems to be practiced mainly by members of the post-millennial generation. RS, described as the experience of being able to transcend one's physical confines and visit alternate, mostly fictional, universes, is discussed by many on Internet platforms. One RS forum...
Abstract Human cerebral organoids (HCOs) are an in vitro three-dimensional model of early neural development, aimed at modelling and understanding brain development and neurological disorders. In just a few years, there has been a rapid and considerable progress in the attempt to create a brain model capable of showcasing the structure and functions of the human brain. There are still strong...