Progress in Brain Research2025Jan Clefferson Costa de Freitas, Nathalia Cristina Medeiros Maia, Markone Brandão Da Silva Shanenawa et al.
The main purpose of this work is to identify the intersections between decolonial thought and psychedelic philosophy. By "psychedelic" we mean a pharmacological category, the effects of substances that modulates perception, a myriad of consciousness states, a set of ecstatic practices, a variety of countercultural movements, a constellation of artistic avant-gardes, and a plurality of ways of...
Over the past 30 years, there has been an increasing scientific and philosophical attention to what contemplative and spiritual traditions for millennia have known as pure consciousness, free from concrete empirical content and egoic self-awareness. The article addresses whether meditation is the best candidate for the research of pure consciousness, as Thomas Metzinger claims in his book The...
Cannabis use represents a significant environmental risk factor for psychotic disorders, with emerging evidence suggesting complex interactions between cannabinoid exposure, dissociative experiences, and fundamental disturbances of self-experience (self-disorders) in early psychosis. This systematic review examines the phenomenological and neurobiological relationships among dissociation,...
This chapter proposes an alternative to the classic models of time-consciousness, called the Extensional-Retentional Analysis of temporal phenomenology, or ERA. ERA represents a pluralistic explanatory strategy as opposed to a “hybrid” view. This strategy sees extensionalism and retentionalism as not only mutually compatible, but synergistic in the sense that each is best suited to explain...
Mindfulness meditation is a systematic training in equanimity, sensory clarity, and concentration rooted in ancient contemplative traditions. Here, we synthesized cognitive-behavioral outcomes in long-term meditators (LTMs) resulting from diverse, prolonged meditation practices. Preliminary evidence suggests that LTMs exhibit increased cognitive-sensory integration and decoupling of affective...
Buddhist meditation, encompassing practices such as Samatha (focused attention), Vipassana (open monitoring), and Metta (loving-kindness), offers unique pathways for transforming consciousness beyond conventional mindfulness. In this article, we review the studies that explore how these distinct meditative techniques systematically cultivate meta-cognitive insight, emotional regulation, and...
Psychedelics are psychoactive substances that cause changes in perception, state of consciousness, mood and numerous cognitive processes. The best known are lysergic acid diethylamide (LSD), N,N-dimethyltryptamine (DMT), psilocybin and mescaline. The main mechanism of action of psychedelics is agonism towards serotonin 5-HT2A receptors. In the middle of the 20th century, interest in the use of...
Despite national efforts to curb the opioid crisis, the clinical and societal challenges continue to grow. FDA-approved medications for opioid use disorder (OUD) are effective but are associated with high rates of treatment discontinuation and relapse. A collection of agents with acute effects on consciousness, collectively (if variably) categorized as 'psychedelics', have emerged as potential...
Hallucinations sit at the crossroads of philosophy and the empirical sciences, but are often approached with divergent aims. In philosophy, they are mainly treated stipulatively as experiences subjectively indistinguishable from veridical perception and used to probe theories of perception, justification, and consciousness. Empirical research, by contrast, investigates heterogeneous, clinically...
Traumatic brain injury (TBI) and near-death experiences (NDEs) represent profound disruptions in brain function, often associated with dramatic changes in consciousness, self-perception, and behavior. While these events are typically studied for their pathological consequences, a growing body of evidence suggests they may also trigger unexpected cognitive and creative enhancements in a subset...