Hypochondriacal obsessive-compulsive disorder (OCD) combines intrusive health anxieties with compulsive reassurance seeking and often resists high-dose selective serotonin reuptake inhibitors and cognitive-behavioural therapy. Interest has shifted toward glutamatergic agents that mimic ketamine's rapid synaptic effects. A 34-year-old woman endured two years of recurrent fear of serious...
Yoga, an ancient mind-body practice originating from India, has gained recognition as a complementary intervention for managing psychiatric disorders. Derived from the Sanskrit term “Yuj,” meaning “to unite,” yoga integrates physical postures (asanas), breath regulation (pranayama), and meditation (dhyana) to promote harmony between body, mind, and spirit. Unlike conventional exercise, yoga...
Discussions around the diagnosis and treatment of developmental trauma continue to evolve, yet a growing body of literature highlights its profound impact on physical, emotional, cognitive, and relational functioning. Developmental trauma often involves coping strategies adapted in response to chronic early-life adversity, including physiological and emotional dysregulation, attachment...
RATIONALE: Major Depressive Disorder (MDD) is a global public health burden, with traditional monoaminergic antidepressants facing critical limitations including slow onset, adverse side effects, and high rates of treatment resistance (TRD). Ketamine, a rapid-acting agent with sustained antidepressant effects, has revolutionized depression treatment paradigms but challenges conventional...
psychiatric disorders, beta-carbolines, trace amine, phosphoproteomics, social hierarchy. Scientific interest in psychedelic substances has re-emerged, offering new perspectives on the treatment of neuropsychiatric and neurological disorders.Historically, psychedelics have been associated with a wide spectrum of positive and negative effects, encompassing ritualistic and spiritual use,...
This article addresses the phenomenon of brain rot, a growing global concern arising from the excessive consumption of low-quality virtual stimuli. Brain rot is associated with persistent anxiety, reduced attention and concentration, mood disturbances, and loss of self-esteem. In the long term, it may contribute to mental and emotional disorders, behavioral addictions, and significant...
bioRxivMarch 13, 2026Brian Lord, Erica N. Lord, Jessica N. Schachtner et al.
preprint
Systematic focus training is increasingly recognized for its therapeutic benefits, with equanimity, the ability to maintain an open and accepting attitude towards all experience, identified as a critical mechanism for improving well-being. Physiologically, experienced meditators demonstrate reduced activity in the posterior cingulate cortex (PCC), a hub of the default mode network (DMN), and...
Aims The recent regulatory approval of esketamine in adults heralded the renaissance of research into psychedelic compounds. However, the relevance of this resurgence for children and adolescents remains unclear. This review examines the rationale for investigating psychedelics in pediatric psychopharmacology. Methods We reviewed recent literature, regulatory documents, and clinical trial...
Serotonergic psychedelics are re-emerging as therapeutic candidates across psychiatry, particularly for treatment-resistant depression. Their rapid and sustained antidepressant effects, alongside evidence for neuroplastic, dopaminergic, and glutamatergic modulation, have prompted interest in whether they could address depressive and negative symptoms in schizophrenia spectrum disorders (SSDs)....
Bloy et al. [1] provide an important and methodologically rigorous secondary analysis of the Ketamine for the reduction of Alcoholic Relapse (KARE) trial, examining whether acute psychoactive effects mediate the therapeutic impact of ketamine in alcohol use disorder (AUD). Their finding that dissociative and perceptual effects did not mediate abstinence outcomes is clinically relevant, and...