The International Journal of Neuropsychopharmacology
September 25, 2023
Szabolcs Koncz, Noémi Papp, Dóra Pothorszki et al.
29 citations
Abstract Background Racemic ketamine consists of two enantiomers, namely (R)-ketamine and (S)-ketamine, with distinguishable pharmacological properties. Both enantiomers have been reported to show rapid antidepressant effects in rodents. Currently, the (S)-enantiomer has been approved for the treatment of major depression, whereas (R)-ketamine failed to show antidepressant effect in recent...
September 18, 2023
Mark Kinet
Is neuropsychoanalysis striving for a theory of everything? If not, then what? Neuroscientific reductionism is contrasted with respect for the living I. Neuropsychoanalysis aims to replace mythology and speculative metapsychology. Neuroplasticity lies at the heart of psychotherapy and psychodynamics. Attachment plays a crucial role in neuronal and psychological development. There are several...
Journal of Community Safety and Well-Being
September 14, 2023
Renae M. Stevenson
The setting of policing exposes its officers to a host of negative health outcomes physiologically, psychologically, and spiritually. Policing mindsets around accessing mental health are far from fixing the epidemic of its mental health crisis or being able to sustain a healthy workforce. Policing is losing the battle with a misguided and a scientifically misinformed war on drugs. Canadian...
2023 11th International Conference on Affective Computing and Intelligent Interaction Workshops and Demos
September 10, 2023
Clemens C C Bauer, Jiahe Zhang, Margaret Niznikiewicz et al.
Numerous mental illnesses have been connected to the dysregulation of particular brain systems. However, few therapy approaches are able to change such specific patterns of brain activity. Nevertheless, this may be accomplished using closed-loop brain imaging techniques like neurofeedback, which aim to directly alter brain activity. Yet, due to methodological issues and the lack of specificity...
Acta Psychiatrica Scandinavica
September 8, 2023
Giacomo D’andrea, Mauro Pettorruso, T. Rhee et al.
8 citations
Depressive disorders represent a significant economic and health burden globally. This is particularly evident in treatment-resistant depression (TRD), commonly defined as the absence of a satisfactory response to at least two different antidepressant trials (as defined by the U.S. Food and Drug Administration/FDA and European Medicine Agencies/EMA). The foregoing TRD cases frequently manifest...
International Conference on Modern Medicine and Global Health
September 7, 2023
H. Hong
SSRIs mediate antidepressant effects by inhibiting specific serotonin transport(SERT) and subsequent modulation of serotonin levels in the brain. This review paper provides an overview of the mechanisms of action of selective serotonin reuptake inhibitors (SSRIs), as well as psychedelics, including their potential therapeutic applications in treating psychiatric disorders. By examining the...
Current Rheumatology Reviews
September 6, 2023
Christine Alexopoulos, Sofia Audrey B. Gonzales, Daniel G. Arkfeld
6 citations
Introduction: Outcomes of treatment for patients with Lupus have shown overall improvement and benefit from the more aggressive use of immunosuppressants and biological agents through a treat-to-target approach. However, chronic musculoskeletal pain can be refractory to treatment despite the use of non-steroidal anti-inflammatory drugs, corticosteroids, and other analgesic agents, leading to...
Brain Behavior and Immunity Integrative
September 1, 2023
Quinn A Conklin, Cavan E. Patterson, Brandon G King et al.
Background: Brain-derived neurotrophic factor (BDNF) is a modulatory neuroprotein implicated in learning, memory, and neuroplasticity. Studies have found increased peripheral BDNF in participants of meditation interventions, indicating that BDNF may play a role in the learning and habit formation that occurs with meditation training. In this study, we assessed changes in peripheral BDNF protein...
Molecular Psychiatry
September 1, 2023
Matthew B. Wall, Rebecca Harding, Rayyan Zafar et al.
39 citations
Psychedelic therapy (PT) is an emerging paradigm with great transdiagnostic potential for treating psychiatric disorders, including depression, addiction, post-traumatic stress disorder, and potentially others. 'Classic' serotonergic psychedelics, such as psilocybin and lysergic acid diethylamide (LSD), which have a key locus of action at the 5-HT2A receptor, form the main focus of this...
Journal of Psychoactive Drugs
August 31, 2023
Alexsandra Kovacevich, Jeremy Weleff, Benjamin Claytor et al.
6 citations
Cultural awareness of anosmia and microsmia has recently increased due to their association with COVID-19, though treatment for these conditions is limited. A growing body of online media claims that individuals have noticed improvement in anosmia and microsmia following classic psychedelic use. We report what we believe to be the first three cases recorded in the academic literature of...