Research Square
July 20, 2023
Orr Shahar, Alexander Botvinnik, Amit Shwartz et al.
3 citations
preprint
Abstract Psilocybin, a naturally occurring, tryptamine alkaloid prodrug, is currently being investigated for the treatment of a range of psychiatric disorders. Preclinical reports suggest that the biological effects of psilocybin-containing mushroom extract or “full spectrum” (psychedelic) mushroom extract (PME), may differ from those of chemically synthesized psilocybin (PSIL). We compared the...
Frontiers in Neuroscience
July 18, 2023
Guy Shapira, Ifat Israel-Elgali, Meitar Grad et al.
Delta-9-tetrahydrocannabinol (THC) is the primary psychoactive compound of the cannabis plant and an exogenous ligand of the endocannabinoid system. In previous studies, we demonstrated that a single microdose of THC (0.002 mg/kg, 3-4 orders of magnitude lower than the standard dose for rodents) exerts distinct, long-term neuroprotection in model mice subjected to acute neurological insults....
International Journal of Gynecological Cancer
July 18, 2023
Dan Yaniv, L. Ramondetta, L. Cohen et al.
Women with gynecologic cancers face various physical and psychological challenges throughout their treatment journey. Late stages associated with poor prognosis, along with chronic side effects of treatment, often leave women with existential uncertainty stemming from unpredictable disease trajectory and continuous fear of death. Recently, a patient in her late 30s (JN) with endstage ovarian...
Pharmaceuticals
July 17, 2023
Glorister A. Altê, Ana Lúcia S Rodrigues
17 citations
Ketamine, a racemic mixture of esketamine (S-ketamine) and arketamine (R-ketamine), has received particular attention for its rapid antidepressant and antisuicidal effects. NMDA receptor inhibition has been indicated as one of the main mechanisms of action of the racemic mixture, but other pharmacological targets have also been proposed. This study aimed to explore the possible multiple targets...
European Chemical Bulletin
July 13, 2023
Lalit Singh
preprint
This review article explores the potential of N,N-Dimethyltryptamine (DMT) as an antipsychotic drug, acknowledging its therapeutic potential while addressing the controversies and potential risks associated with its use. DMT has distinctive effects on fast brain plasticity and functions as a serotonin agonist hallucinogen, primarily at the 5-HT2A receptor, immune-modulation, and in influencing...
Open Access Government
July 13, 2023
Cosmo Feilding-Mellen
Using psychedelics to mitigate Treatment Resistant Depression Cosmo Feilding-Mellen, CEO, Beckley Psytech, charts the role of psychedelics in mitigating Treatment Resistant Depression. When it comes to treating neuropsychiatric and mental health conditions, we have to accept that one size does not fit all. For some, talking therapies like cognitive behavioural therapy plus antidepressants like...
Clinical Psychopharmacology and Neuroscience
July 10, 2023
Jeongseop Kim, Tae-Eun Kim, Seung Hwan Lee et al.
29 citations
The monoamine hypothesis has significantly improved our understanding of mood disorders and their treatment by linking monoaminergic abnormalities to the pathophysiology of mood disorders. Even 50 years after the monoamine hypothesis was established, some patients do not respond to treatments for depression, including selective serotonin reuptake drugs. Accumulating evidence shows that patients...
Elife
July 7, 2023
Sofie Louise Valk, Philipp Kanske, Bo-Yong Park et al.
The human brain supports social cognitive functions, including Theory of Mind, empathy, and compassion, through its intrinsic hierarchical organization. However, it remains unclear how the learning and refinement of social skills shapes brain function and structure. We studied if different types of social mental training induce changes in cortical function and microstructure, investigating 332...
Brain Network and Modulation
July 1, 2023
Javier Hidalgo Jiménez
2 citations
N,N-dimethyltryptamine (DMT) is the simplest psychedelic tryptamine and is produced naturally by many plant and animal species, including humans. While classical psychedelics, such as lysergic acid diethylamide, or psilocybin, are gaining interest because of their therapeutic potential, DMT has yet to be fully investigated. However, preliminary clinical evidence suggests that DMT and/or...
Frontiers in Integrative Neuroscience
June 30, 2023
Katarina Ilić, Rita Bertani, Neda Lapteva et al.
11 citations
Background: The presence of visual imagery in dreams of congenitally blind people has long been a matter of substantial controversy. We set to systematically review body of published work on the presence and nature of oneiric visuo-spatial impressions in congenitally and early blind subjects across different areas of research, from experimental psychology, functional neuroimaging, sensory...