ACS Medicinal Chemistry Letters
January 11, 2024
Robert B. Kargbo
1 citation
Psychedelic compounds, including ketamine and LSD, have gained renewed interest as potential treatments for neuropsychiatric disorders. These compounds act as psychoplastogens, promoting neuronal growth by activating AMPA receptors, TrkB, and mTOR. The prefrontal cortex plays a crucial role in their therapeutic effects through top-down control over brain regions involved in motivation, fear,...
Research Square
January 4, 2024
Laetitia Vanderijst, Felix Hever, Anne Buot et al.
preprint
Abstract Background: A significant number of individuals with alcohol use disorder remain unresponsive to currently available treatments, which calls for the development of new alternatives. In parallel, psilocybin-assisted therapy for alcohol use disorder has recently yielded promising preliminary results. Building on extant findings, the proposed study is set to evaluate the feasibility and...
Proceedings of the Second Southern Science Conference. Book B
2024
N. González, P. Ramirez, Esther Berenice Vargas Hunger et al.
Ketamine-induced psychotic episodes with hallucinations and sensory dissociation when abused. In rats, prolonged intraperitoneal ketamine (K) administration increases locomotor activity. Neuroactive steroids modulate responses to such drugs. This study aimed to investigate ketamine-induced neuroadaptive effects and neuromodulatory phenomena from Estradiol (E2) and Progesterone (P4) in female...
Frontiers in Psychology
2024
Sharon Vaisvaser
Intriguing explorations at the intersection of the fields of neuroscience and psychology are driven by the quest to understand the neural underpinnings of "the self" and their psychotherapeutic implications. These translational efforts pertain to the unique Creative Arts Therapies (CATs) and the attributes and value of the self-related processes they offer. The self is considered as a...
Frontiers in Neuroscience
2024
Kensaku Mori, Hitoshi Sakano
When we are awake and relaxed, various memory-scenes come up in our mind by spontaneous activation of memory engrams. We find ourselves in the memory-scene longing for it by the present self. The memory scene is also recollected by sensory inputs from the surrounding world for learned behavioral decisions. It is well experienced that odorants act as strong cues in remembering associated memory....
UC Merced Undergraduate Research Journal
2024
Jose Miranda
Psychedelic substances, which were once categorized as Schedule 1 drugs, are gaining public attention for their potential to treat individuals with mental conditions. Every Schedule 1 drug was once considered to have no medicinal value, with the potential for high abuse, but recent research has suggested otherwise. LySergic acid Diethylamide (LSD) and MethyleneDioxy-MethAmphetamine (MDMA) are...
Medical Research Archives
2024
Daniel Kleinloog
Ketamine is a dissociative anesthetic with unique pharmacological and psychological properties. Its antidepressant effects are mediated through the glutamatergic system and subsequent neuroplasticity and can be amplified when combined with psychotherapy. The ketamine-induced dissociative state should not be seen as an unwanted side-effect, but as a unique opportunity for psychotherapeutic...
Frontiers in Psychology
2024
Hugo Toriz, Antonella Fagetti, Guadalupe Terán-pérez et al.
5 citations
In Mexico, shamans are recognized for the gift of entering a deep trance that allows them to know the origin of the diseases and conflicts that afflict people. They commonly treat patients through limpias (cleansing) to extract negative elements sent by a witch or that were "collected" in places that harbor "evil winds." We present a case study of an 81-year-old Mexican shaman who noticed her...
Perspectives in biology and medicine
2024
Dominic Sisti
1 citation
Introduction to the Special Section on Psychedelics Research and Treatment Dominic Sisti Against a backdrop of post-pandemic malaise, diseases of despair, and a fragmented mental health care system, psychedelics have enjoyed a resurgence of interest as powerful psychotherapeutic agents and as catalysts of personal growth. The true power of these substances—some of which are considered...
Journal of the Netherlands Society of Toxicology
2024
Marcha Verheijen
1 citation
Depression, affecting over 264 million people globally, presents significant treatment challenges, often due to the limited efficacy and adverse effects of traditional antidepressants and the accessibility issues associated with psychotherapy. Recent advancements in psychedelic-assisted therapy, particularly using psilocybin, a naturally occurring compound found in “magic mushrooms”, shows...