Archiv EuromedicaDecember 26, 2024Jakub Prosowski, Szczepan Pośpiech, Michał Piotrowski et al.
Aims: This review aims to explore the efficacy, mechanisms, administration routes, and safety profiles of ketamine and esketamine in the treatment of treatment-resistant depression (TRD). Methods: A comprehensive review of recent studies on ketamine and esketamine’s therapeutic applications in TRD was conducted. Sources included randomized controlled trials, systematic reviews, and...
Alcohol is a harmful drug, and reducing its consumption is a significant challenge for users. Furthermore, alcohol dependence is often treatment-resistant, and no completely effective treatment model is available for chemical dependence. Classic psychedelics, such as LSD, psilocybin, and ayahuasca have been used in different clinical and pre-clinical trials, demonstrating promising...
Abstract In this chapter, the authors synthesize the relational developmental perspective of attachment theory with a neuroscientific model: the RElaxed Beliefs Under pSychedelics (REBUS). This synthesis, the authors argue, can serve as an organizing framework for psychedelic science. Attachment theory posits that people develop internal working models (IWMs) of relational experiences with...
Dr. Alaina M. Jaster is a postdoctoral scholar in the Department of Psychiatry and Behavioral Neurosciences at Wayne State University. She currently serves on the trainee editorial board of Psychedelic Medicine, the journal for the International Society for Research on Psychedelics (ISRP), and is part of the Society's Diversity Equity Inclusion and Accessibility committee. Jaster is also part...
Abstract Psilocybin is a psychedelic tryptamine that has emerged as a potential candidate for the treatment of a variety of conditions, including treatment resistant depression and post-traumatic stress disorder. Clinical trials which have assessed the efficacy of psilocybin for these conditions report a rapid and sustained improvement in patient- and clinician-rated depression scores. The...
Recent studies indicate that nitrous oxide (N2O), a gaseous anesthetic and an NMDA (N-methyl-D-aspartate) receptor antagonist, produces rapid antidepressant effect in patients suffering from treatment-resistant depression. Our recent work implies that hypothermia and reduced energy expenditure are connected with antidepressant-induced activation of TrkB neurotrophin receptors - a key regulator...
SUMMARY We quantify cellular- and circuit-resolution neural network dynamics following therapeutically relevant doses of the psychedelic psilocybin. Using chronically implanted Neuropixels probes, we recorded local field potentials (LFP) alongside action potentials from hundreds of neurons spanning infralimbic, prelimbic and cingulate subregions of the medial prefrontal cortex of...
Background: Parkinson’s disease (PD) is the second most common neurodegenerative disorder, characterized by progressive loss of dopaminergic neurons, leading to both motor and non-motor symptoms. Although dopaminergic therapy is the current goldstandard therapy in symptomatic management, it does not alter disease progression. Meditation, a complementary therapy, has shown promise in alleviating...
TeosofiaDecember 9, 2024Teten Jalaludin Hayat, Nasihun Amin, N. Nizar
This study examines the epistemology of Sufi healing as presented in Miftāḥ al-Ṣudūr by Pangersa Abah Anom. Employing a descriptive qualitative methodology and the Miles and Huberman analysis model, the research explores how classical Sufi concepts—such as tazkiyyah, takhliyyah, and tanfiyyah—are integrated with modern empirical insights from psychology and neuroscience to form a holistic...
Brain-derived neurotrophic factor (BDNF) is critical for neuroplasticity, synaptic transmission, and neuronal survival. Studies have implicated it in the pathophysiology of depression, as its expression is significantly reduced in brain areas such as the prefrontal cortex and hippocampus in patients with depression. Our narrative review focuses on the relationship between BDNF, ketamine, and...