Interest in psychedelics is booming, heralding a possible psychedelic renaissance in the United States. But policy makers interested in expanding access to psychedelic substances would be wise to heed lessons gleaned from the past 25 years of marijuana law reforms. That experience suggests that it may prove impossible to repeal or narrow the federal ban on psychedelics in the near term, but...
Abstract Background: Understanding the phenomenology and content of the inhaled N, N, dimethyltryptamine (N, N-DMT) experience is critical to facilitate and support ongoing research and therapeutic models targeting mental health conditions and central nervous system pathology. Methods: Qualitative analysis of all N, N-DMT experiences posted to the r/DMT Reddit community over a 10-year period...
Classic psychedelics are a loosely grouped class of drugs that activate serotonin 5HT2A receptors to induce complex behavioral, psychological, and physiological effects [1]; 5HT2A agonism induces the hallucinogenic experiences that distinguish psychedelics [2] while pre-medicating with a 5HT2A antagonist, such as ketanserin, prevents them [3,4]. In the 1950s and 1960s, after Albert Hoffman’s...
the religious and spiritual aspects of Wittgenstein, his understanding of ‘das mystiche’ and his philosophy understood against the background of German mysticism has been commented on by authors to help explain the ethical aspects of the early Wittgenstein (1922), particularly the Tractatus, and also his later work. Some maintain that the mystical is an element uniting his philosophy and that...
While studies on the characteristics of flow states and their relation to peak performance exist, little is known about the dynamics by which flow states emerge and develop over time. The current paper qualitatively explores the necessary pre-conditions to enter flow, and the development of flow over time until its termination. Using an elicitation interview, participants (10 athletes and 12...
Rationale: Recent trials with psychedelics in major depressive disorder and treatment-resistant depression showed remarkable improvements in depressive symptoms that can last for up to several months after even a single administration. The lack of an appropriate placebo control group-as patients are often able to discriminate the subjective effects of the drug-and an incomplete understanding of...
Introduction Although the topic of consciousness is both mysterious and controversial, psychedelic drugs are popularly believed to provide unique insights into the nature of consciousness despite a lack of empirical evidence. Methods This study addresses the question of whether psychedelics change the attribution of consciousness to a range of living and non-living entities. A survey was...
This article is the result of a compare analyses of the treatise by Pseudo- Dionysius the Areopagite «Mystical Theology» and one of the central sutras of the Mahayana’s tradition «The Heart Sutra». This article has the following objectives: firstly, to conduct a comparative analysis of two fundamental texts, in which displayed the central categories of each tradition. Special attention was paid...
Strategically timed trauma- and attachment-informed psychotherapy to address underlying emotional wounds, paired with ketamine administered in precision-calibrated doses to ensure high-entropy brain states, may be key to improving the quality and duration of ketamine’s therapeutic efficacy for treatment-resistant depression. This approach optimizes the opportunities for change created by...
Recently there has been a surge of renewed interest in the psychedelic compound psilocybin. In particular, psilocybin is being studied in clinical settings as a potential breakthrough treatment for depression. Alongside this growing therapeutic interest, there has been a rise in the religious use of psilocybin, as evidenced by the creation of a number of psilocybin mushroom churches in the...