To investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of BPL-003, a novel intranasal benzoate salt formulation of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), in healthy participants. In all, 44 psychedelic-naïve participants enrolled in the double-blind, placebo-controlled single ascending dose study (1-12 mg BPL-003). Concentrations of 5-MeO-DMT and its...
Context: Students of color in the United States experience elevated stress across the entire spectrum of education, spanning from early stages of K-12 to the more advanced stages of postgraduate studies. This sustained state of chronic stress decreases learning and curtails opportunities, especially in science, technology, engineering, and math (ST EM) fields, where stress levels are considered...
This chapter proposes an archeology of the category mysticism, showing its different meanings in the Christian religious context, and then in human and social sciences. It argues that despite its essentialist uses in the 20th and 21st centuries, this category can still be relevant and effective. Instead of considering mysticism as a phenomenon separated from religion, limited to the private...
This narrative review explores the utilization of psychedelic states in therapeutic contexts, deliberately shifting the focus from psychedelic substances back to the experiential phenomena they induce, in alignment with the original meaning of the term "mind-manifesting." The review provides an overview of various psychedelic substances used in modern therapeutic settings and ritualistic...
This article proposes a model of comparative mysticism that bases its rationale for comparison in the dynamic interaction between three components: neurocognitive mechanisms and substrates, phenomenal experiences, and noetic accounts. In examining the phenomenon of ego - dissolution ( EDn ), using this model, a scholar can identify universal and contextual components of a mystic’s experiences....
The concept of the imagination, has been an important area of philosophical and religious inquiry. But this concept is often neglected in connection with the Islamic mystical tradition even though the faculty of the imagination (khayāl) plays a central role in mystical experience. This article will address the role imagination in the thought of the famous mystic Ibn ‘Arabī. It will demonstrate...
Time can be a difficult concept to understand. Albert Einstein, who viewed time as an illusion, explained the passage of time is relative to the observer’s frame of reference in the space-time continuum. However, the state of consciousness of the observer also influences the passage of time. This paper examines the relationship between the experience of time and different states of...
While effective, medication for opioid use disorder (MOUD) treatment outcomes can be limited by co-occurring polysubstance use, mental health and chronic pain conditions. Interoceptive training may facilitate well-being and support medication treatment for MOUD. This study examined the pre-post effects of the mindfulness-based intervention Mindful Awareness in Body-oriented Therapy (MABT) as an...
Abstract Psychedelic substances, which can occasion mystical experiences, are sometimes used for religious and spiritual reasons. Despite strong links between psychedelics and spirituality, no previous systematic review has investigated connections between psychedelics and indicators of long-term spiritual growth. Thus, 34 empirical studies were analyzed with 19,724 total participants from 32...
Fruitful comparison of psychedelic, spiritual, and psychotic experiences requires a degree of phenomenological nuance. Some shared features of these phenomena, such as encounters and communications with supernatural entities, are obfuscated by scientific and clinical terminology. Other supposed distinctions are based on an atemporal view of dynamic experiences. In Section 2 of this...