After decades of stagnancy, research on psychedelic substances (such as LSD, psilocybin or DMT) has experienced a renaissance over the last 10 years, with various major research programs being conducted across Europe and the United States. This research primarily investigates the potential of psychedelics in the treatment of mental health disorders, their short and long term effects on...
Introduction There is a growing and renewed interest in the use of hallucinogenic drugs in the treatment of psychiatric disorders, especially since the FDA approval of esketamine treatment for resistant depression. The response to hallucinogenic psychedelic substances (ayahuasca, psilocybin, LSD, ketamine) in the treatment of depression and addictions calls for a theoretical explanatory model....
Teneisha M. Myers, Noah C. Neverette, Aaron S. Devanathan et al.
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Abstract Rationale Cannabis is the most widely used illicit substance in the United States, and its use is increasing with the recent push for legalization and decriminalization, as well as the growing use for medicinal purposes. While cannabis can have positive effects in some individuals, there are potential negative consequences including dependence, psychosis, and cognitive impairments. The...
Autism spectrum disorder (ASD) and schizophrenia (SCZ) are diagnostically demarcated disorders, yet overlapping pathological functioning is reported at several levels of organisation starting from brain circuitry to behaviour, complicating diagnostic differentiation. In particular, what the two disorders seem to share is anomalous minimal self experience, which is a trait-like, phenomenological...
Mindfulness may be defined as the non-focal awareness of consciousness as the condition of all one’s focal awareness. Cultivating mindfulness is a powerful discipline for corporate leadership development. Beyond performance enhancement, mindfulness can elicit transformative awareness of the conditions of better leadership. Mystical mindfulness—the product of mystical experience reflectively...
Aim: N,N-dimethyltryptamine (DMT) is a psychedelic compound under development for the treatment of major depressive disorder (MDD). This study evaluated the in vitro metabolism and clinical pharmacokinetics (PK) of DMT fumarate (SPL026) in healthy subjects. Methods: Results are from the Phase I component of an ongoing Phase I/IIa randomised, double-blind, placebo-controlled, parallel-group,...
El fenómeno místico se entiende como una experiencia profunda y límite de la realidad, donde el ser humano llega a un estado de conciencia tal que trasciende los conceptos ordinarios con los que entendemos el mundo. Dicha experiencia sugiere una noción de la realidad según la cual existe un orden subyacente a los fenómenos físicos (la realidad fundamental) y diferente a los mismos, donde todo...