The combined microdose of NPK and urea could be a sustainable intensification strategy for sesame cultivation in semi-arid areas of West Africa.This study evaluated the effects of different NPK microdose treatments, both alone and in combination with urea, on sesame productivity and economic profitability in the North Sudanese zone of Burkina Faso.The trial was conducted in 2019 and 2020 at the...
The biophysical field-based evaluation of the endogenous soil and water conservation (SWC) practices in the hilly region of sub-Saharan West Africa is lacking. To address this, the current study aims to evaluate the most commonly used erosion control practices in the hilly region of Boukombé through a rainfed field experiment conducted under sorghum over two growing seasons (2012–2013) on a...
IntroductionMicrodosing psilocybin magic mushrooms (MM) and truffles has grown in popularity, but the evidence supporting reported benefits remains poorly characterized. The purpose of this systematic review was to synthesize the existing literature on microdosing psilocybin MM and truffles in adults to determine reported health effects and perceived benefits, motivations for use, dosing...
Abstract Background Current gender-affirming hormone therapy (GAHT) guidelines are optimized for binary outcomes (full masculinization or feminization), leaving a critical evidence gap for the growing population of non-binary and gender-diverse (NBGD) individuals who seek partial physical changes. These non-traditional therapeutic goals often necessitate the off-label use of low-dose,...
Pearl millet ( Pennisetum glaucum (L.) R. Br) is a very important cereal crop in the semi-arid regions of West Africa, serving as a primary food source for local populations. Therefore, its productivity remains lowered by soil degradation and low availability of inputs as fertilizers. In this context, biofertilizers and organic amendments offer sustainable and ecological alternatives for...
CureusJuly 2026Mia A Panlilio, Natalie Piserchio, Mercedes Hennessey et al.
Glucagon-like peptide-1 (GLP-1) is an endocrine hormone that plays a role in lowering blood glucose levels and promoting weight loss. GLP-1 receptor agonists (GLP-1 RAs) are synthetic peptides that mimic the activity of GLP-1, and the recent development of GLP-1 RA medications has been a major historical advancement in the treatment of diabetes and obesity. Despite the rapid development of...
Psilocin (4-hydroxy-N, N-dimethyltryptamine) is a substituted tryptamine alkaloid and a nonselective serotonergic agonist acting predominantly at 5-HT2A/C receptors, with substantial binding to 5-HT1A and 5-HT2B receptors. Microdosing is the practice of taking a very small, sub-perceptual dose, typically 5% to 10% of a full recreational dose, to improve mood, creativity, and focus without...
Background: Psychedelic microdosing—repeated sub-perceptual doses of lysergic acid diethylamide (LSD) or psilocybin—has attracted scientific interest as a potential mood and cognitive intervention. The evidence base remains methodologically heterogeneous and vulnerable to expectancy bias. Methods: We conducted an umbrella review with narrative synthesis following Joanna Briggs Institute...
= 26.38, ~50% past-month cannabis use by design) completed an online survey. Multivariable regression assessed sociodemographics, mental health, and adverse childhood events (ACEs) in relation to: (1) past-year psychedelic use; and (2) among those reporting lifetime use: (a) lifetime microdosing and (b) use motives. Lifetime and past-year psychedelic use were 27.7% and 11.9% (commonly...
Microdosing and related low-dose psychoactive practices have become increasingly visible in discussions of mental health, cognition, creativity, emotional regulation, pain, sleep, spirituality, and psychological flexibility. However, the term microdosing is often used as if it referred to a single pharmacological phenomenon. More precisely, it describes a low-dose application pattern used...